# tutorial 1 assignment

Good Essays
1410 Words
Grammar
Plagiarism
Writing
Score
tutorial 1 assignment
Tutorial 1
1. pK = 3.4
DH = ASA
Plasma pH = 7.3 Stomach pH = 1.5 = 10pH – pK = 10pH – pK = 107.3 – 3.4 = 101.5 – 3.4 = 7943.2823 = 0.01259

[Total Drug] = [D-] + [DH] [Total Drug] = [D-] + [DH] = 7943.2823 + 1 = 0.0126 + 1 = 7944.2823 = 1.0126

[Total Drug] in stomach relative to plasma = 7944.2823/1.0126 = 7845.43

Conclusion: High absorption of ASA from the stomach lumen. Absorption from stomach is 7845.43 times greater than in the plasma.

2. At pH 1.4 At pH 7.4 At pH 1.4 At pH 7.4
A1 (pK = 3.4) A1 (pK = 3.4) B1 (pK = 7.4) B1 (pK = 7.4) = 101.4 – 3.4 = 107.4 – 3.4 = 101.4 – 7.4 = 107.4 – 7.4 = 0.01 = 10000 = = 1
%D- = x100% %D- = x100% %DH+ = x100% %DH+ = x100% = 0.99% = 99.99% = 100.00% = 50.00% A2 (pK = 4.4) A2 (pK = 4.4) B2 (pK = 8.4) B2 (pK = 8.4) = 101.4 – 4.4 = 107.4 – 4.4 = 101.4 – 8.4 = 107.4 – 8.4 = 0.001 = 1000 = = 0.1
%D- = x100% %D- = x100% %DH+ = x100% %DH+ = x100% = 0.10% = 99.90% = 100.00% = 90.91%

A3 (pK = 5.4) A3 (pK = 5.4) B3 (pK = 9.4) B3 (pK = 9.4) = 101.4 – 5.4 = 107.4 – 5.4 = 101.4 – 9.4 = 107.4 – 9.4 = 0.0001 = 100 = = 0.01
%D- = x100% %D- = x100% %DH+ = x100% %DH+ = x100% = 0.01% = 99.01% = 100.00% = 99.01%

3. DH = sulfonylureas

At pH = 5 At pH =6.5
Metsulfuron-methyl (pK = 3.3) Metsulfuron-methyl (pK = 3.3) = 105 – 3.3 = 106.5 – 3.3 = 50.1187 = 1584.8932 %DH = x 100% %DH = x 100% = 1.96% = 0.063%

Chlorsulfuron (pK = 3.7) Chlorsulfuron (pK = 3.7) = 105 – 3.7 = 106.5 – 3.7 = 19.9526 = 630.9573 %DH = x 100% %DH = x 100% = 4.77% = 0.16%

Triasulfuron (pK = 4.6) Triasulfuron (pK = 4.6) = 105 – 4.6

## You May Also Find These Documents Helpful

• Satisfactory Essays

The following items appeared in the accounting records of Triguero's, a retail music store that also sponsors concerts.…

• 1409 Words
• 34 Pages
Satisfactory Essays
• Satisfactory Essays

Do you have a DNS Server set up with your company? If so, what kind?…

• 128 Words
• 1 Page
Satisfactory Essays
• Satisfactory Essays

Video Connectors – Video Graphics Adapter (VGA), Digital Video Interface (DVI), and S-Video (TV connection)…

• 383 Words
• 2 Pages
Satisfactory Essays
• Good Essays

1. Microsoft is aware that research was published at a security conference proving a successful attack against X.509 digital certificates signed using the MD5 hashing algorithm. This attack method could allow an attacker to generate additional digital certificates with different content that have the same digital signature as an original certificate. The MD5 algorithm had previously shown a vulnerability, but a practical attack had not yet been demonstrated.…

• 676 Words
• 3 Pages
Good Essays
• Powerful Essays

The two main nano-sized particles that may be applied to construction materials in the future are titanium dioxide (TiO2) and carbon nanotubes (CNTs) (Smith, 2012)…

• 2077 Words
• 9 Pages
Powerful Essays
• Good Essays

The purpose of this policy is to define standards for connecting to Richman Investments network from any host. These standards are designed to minimize the potential exposure to Richman Investments from damages which may result from unauthorized use of Richman Investments resources. Damages include the loss of sensitive or company confidential data, intellectual property, damage to public image, damage to critical Richman Investments internal systems, etc.…

• 479 Words
• 2 Pages
Good Essays
• Satisfactory Essays

5. How long do you think it will take before the IPv4 addresses are completely exhausted? It could possibly become exhausted within the next two years or so.…

• 310 Words
• 1 Page
Satisfactory Essays
• Satisfactory Essays

In the given network diagram, several domains need to be considered. This diagram includes the User, Workstation, LAN, and LAN-to-WAN domains. Security controls and their implementation are discussed below.…

• 333 Words
• 1 Page
Satisfactory Essays
• Good Essays

1. Research the following organizations and explain their involvement with the Internet public IP addresses:…

• 375 Words
• 2 Pages
Good Essays
• Better Essays

4. According to this chapter, which of the following concepts happens in a modern-day, end-to-end voice call between two home telephones in the United States? (Choose two answers.)…

• 1061 Words
• 5 Pages
Better Essays
• Good Essays

The first half of module seven discussed protein digestion, absorption, and metabolism; while the second half focused on pathological stress and kidney disease. Protein digestion occurs in the stomach and small intestine. When a protein reaches the stomach it is denatured by hydrochloric acid. Once the protein is digested pepsin breaks apart the denatured protein into peptides. Peptides move into the small intestine where they encounter an enzyme that digest the peptides into di- or tripeptides, then into single amino acids. Once the protein is digested into single amino acid groups, then the amino acids can be absorbed into the intestinal epithelial cells. The amino acids are moved from the intestinal epithelial cells into the capillaries of the intestinal villi. From the capillaries of the intestinal villi,…

• 430 Words
• 2 Pages
Good Essays
• Satisfactory Essays

A multimedia essay combines textual content and multimedia elements to create a unique and inventive version of an essay to share with others. In this activity, you will use textual material from your literary essay and multimedia elements such as sound, layout, video, images, web-quests, etc. to create a unique version of your essay to share with your classmates.…

• 582 Words
• 3 Pages
Satisfactory Essays
• Satisfactory Essays

Living with Hodgkin’s disease is not easy. Being diagnosed with Hodgkin's disease changes everything in your life, and the lives of those around you. People living with cancer may worry about what the future holds. They may worry about holding their jobs, caring for their families, personal relationships, or continuing with daily activities. Concerns about tests, treatments, hospital stays, and medical bills are also common. Doctors, nurses, and other members of the health care team can answer questions about treatment, working, or other activities. Meeting with a social worker, counselor, psychologist, or member of the clergy can be helpful to people who want to talk about their feelings or discuss their concerns. Often, a social worker can suggest groups that can help with rehabilitation, emotional support, financial aid, transportation, or home care.…

• 260 Words
• 1 Page
Satisfactory Essays
• Powerful Essays

Calculation: (11,834,883 + 3,845,900 + 3,696,800 + 3,650,647) / 44,582,621 = 0.5165292996 = 0.516 (3dp) =51%…

• 2703 Words
• 11 Pages
Powerful Essays
• Good Essays

L(G) = ({S, A, B}, {a, b},{ S  ASB | ; A  aAb | ; B  bBa | ba}, S}…

• 3288 Words
• 14 Pages
Good Essays