Trends

Good Essays
Pentacyclic Triterpene Distribution in Various Plants – Rich
Sources for a New Group of Multi-Potent Plant Extracts
Sebastian Jäger 1,*, Holger Trojan 1, Thomas Kopp 1, Melanie N. Laszczyk 2 and Armin
Scheffler 1
1
2

Carl Gustav Carus-Institute, Am Eichhof 30, D-75223 Niefern-Öschelbronn, Germany
Betulin-Institute, Blumenstrasse 24, D-64297 Darmstadt, Germany;
E-Mail: m.laszczyk@betulin-institut.de (M-N.L.)

* Author to whom correspondence should be addressed; E-Mail: sebastian.jaeger@carus-institut.de;
Tel.: +49 7233 68 410; Fax: +49 7233 68 413
Received: 22 April 2009; in revised form: 26 May 2009 / Accepted: 3 June 2009 /
Published: 4 June 2009

Abstract: Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark. In particular the lupane-, oleanane-, and ursane triterpenes display various pharmacological effects while being devoid of prominent toxicity. Therefore, these triterpenes are promising leading compounds for the development of new multi-targeting bioactive agents. Screening of 39 plant materials identified triterpene rich (> 0.1% dry matter) plant parts. Plant materials with high triterpene concentrations were then used to obtain dry extracts by accelerated solvent extraction resulting in a triterpene content of
50 - 90%. Depending on the plant material, betulin (birch bark), betulinic acid (plane bark), oleanolic acid (olive leaves, olive pomace, mistletoe sprouts, clove flowers), ursolic acid (apple pomace) or an equal mixture of the three triterpene acids (rosemary leaves) are the main components of these dry extracts. They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical formulations.
Keywords: lupane; oleanane; ursane; triterpene dry extract; active plant extracts; triterpene distribution

Molecules 2009, 14

2017

Introduction
Consumption of fruit and



References: Chem. 2009, 57, 3604-3610. enterococci (VRE). Biol. Pharm. Bull. 2007, 30, 1147-1149. pentacyclic triterpenoids in plants by GC-EI/MS. Phytochem. Anal. 2006, 17, 102-106. antitumor agent. J. Health Sci. 2008, 54, 654-660. http://www.liberherbarum.com/ (27.03.2009), Chaturvedi, P.K.; Bhui, K.; Shukla, Y Fulda, S. Betulinic acid for cancer treatment and prevention. Int. J. Mol. Sci. 2008, 9, 1096-1107. Liu, J. Oleanolic acid and ursolic acid: research perspectives. J. Ethnopharmacol. 2005, 100, 9294. 13, 3224-3235. Duke, J. Dr. Duke 's Phytochemical and Ethnobotanical Databases. http://www.arsgrin.gov/duke/plants.html (27.03.2009), Laszczyk, M.; Jäger, S.; Simon-Haarhaus, B.; Scheffler, A.; Schempp, C.M Res. 1998, 8, 78. spectrometry. J. Mass Spectrom. 2003, 38, 723-731. Molecules 2008, 13, 2482-2487.

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