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The Synthesis Of Alzheimer's Disease

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The Synthesis Of Alzheimer's Disease
In Alzheimer's disease, the brain cells degenerate and die, causing a steady decline in memory and mental function. AD is characterized by cognitive impairment, progressive neurodegeneration and formation of amyloid-b (Ab)-containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau. The neurodegenerative process in AD is initially characterized by synaptic damage with neuronal loss. In addition, latest evidence reveal that change in adult neurogenesis in the hippocampus might be a factor. Synaptic loss is one of the strongest associate to the cognitive impairment in patients with AD. Several lines of investigation support the concept that the synaptic pathology and defective neurogenesis in AD are related to progressive
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