The Causes Of Preclinical AD

As previously mentioned, preclinical AD begins approximately 15 years before the cognitive system actually begins to get impacted by the chemical imbalances of the brain. The cause of preclinical AD revolves around the formation of amyloid plaques that begin to slowly deposit in various regions of the brain, particularly forming in the hypothalamus and the cerebral cortex which are areas imperative to regulating one’s circadian clock; the amyloid plaques form gradually over time as the disease progresses due to sleeplessness, the earliest symptoms being sleep-wake disturbances and prolonged wakefulness (Limm et al., 2014). The more plaque there is in these important regions, the more sleep-wake fragmentation occurs in the person, usually stemming