The Alzheimer Disease

Topics: Alzheimer's disease, Brain, Neuron Pages: 5 (1544 words) Published: November 4, 2009
“The Alzheimer Disease”
1. Source Article
Alzheimer’s Association National Office (June 2008)
A German physician Alois Alzheimer named Alzheimer’s a brain disorder in 1906. This is a fatal brain disease affecting 5 million Americans today. Alzheimer’s is the 6th leading cause of death around the world. It is most common tern for memory loss. It also causes loss of intellectual abilities. It is a gradual disease that can interfere with daily life. I get worse over time and can become fatal. 2.) Source Article

Psychiatry, Amy “Early Stages of Alzheimers”1994 Mar 15 Alzheimer’s is more than a simple loss of memory. People with Alzheimer’s experience difficulty in communication, learning, thinking and reasoning. There are seven warning signs: 1. Asking the same question over and over

2. Repeating the same story word for word, again and again 3. Forgetting activities that were cone with ease
4. Forgetting how to pay bills or balance a check book
5. Getting lost in familiar surroundings
6. Neglecting taking baths or changing into clean clothes 7. Relying on the spouse to answer simple question that were previously answered easily by them. 3.) Source Article
Pia, Lorenzo and Conway, Paul M.(Alzheimer’s disease) May 2008 Vol. 9 People who have AD show reduction of cerebral haematic flow in the frontal regions of the brain. The person also has deficits of executive functions and extra pyramidal signs. Depression could be interpreted as an adaptive behavior to counter the effects of perceived loss of cognitive abilities. Self awareness in AD could have some common mechanisms with auto – monitoring in schizophrenia. AD is characterized by the significant reductions of cerebral weight and by cortical atrophy, with the widening of the cerebral sulci and the leveling of the cerebral convolutions. The most relevant and distinctive lesional patterns are neuronal degeneration, congophilic angiopathy and senile plagues and neurofibrillary degeneration. AD results from multifocal lesions rather than a global generation of the cerebral tissue. The first neuroradiologic examination is usually negative. A confirmed diagnosis is possible only after post mortem examination. A good diagnostic approximation can be reached through neuroradiologic evidence, in the presence of progressive memory deficits, in the absence of consciousness alternations. 4. Source Article

Journal of Psychiatry and Neuroscience (May 2008) Vol 33 Issue 3 Depressive symptoms of varying severity are prevalent in up to 63% of patients with AD. When depression is present it can result in more cognitive decline. Very little is known about the underlying mechanisms of depressive symptoms in the patients. It is likely that depressive symptoms in AD are multifactorial. Abnormalities in the limbic-frontal circuitry have been associated with depressive symptoms in AD patients. Mayberg and colleagues proposed a working model of primary depression that involves 3 interconnected frontal regions. The dorsal, ventral and rostral cingulated. The dorsal is involved in the cognitive aspects of negative emotion. The ventral may mediate the circadian and vegetative aspects of depression such a disturbed sleep and appetite. The rostral mediates interactions between dorsal and ventral cortical subcortical pathways. 5. Source Article

Chang, C.L “Obesity and Alzheimer’s Disease
Alzheimer’s disease accounts for 50%-60% of all patients with dementia. The need for a life course on the approach to understanding the causes of AD was recognized because the consequences and timing of the AD are relevant throughout life. There is increasing evidence that vascular risk factors, such as hypertension, high cholesterol levels and diabetes mellitus are also relevant, which often occur together with obesity. These two diseases are very common among the elderly. Obesity is believed to increase the risk of AD through the amyloid cascade, leptin...
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