Systemic Lupus Erythematosus Essay

INTRODUCTION:

- Systemic lupus erythematosus (SLE) is an autonomous disorder with variety of autoantibodies (double stranded DNA [dsDNA], ANA). It causes inflammation diffusely through the body (skin, brain, kidneys, and joints) and also the blood. Lupus has varied abnormal blood tests related to it (anemia, anti-Sm, anti-phospholipid antibodies), however this is often not a similar issue as knowing what causes lupus. Its cause could be a mystery. The etiology of lupus is unknown, however multiple genetic, epigenetic, and environmental risk factors are involved. The inheritance of genes alone isn't enough for developing lupus, suggesting the influence of environmental triggers on unwellness expression. Despite the numerous role of the surroundings
Over fifty genes found to play a job in lupus, however none found to be shown the exact/firm phenomena (Webb R, 2011). Though alterations in diet will cut back the danger of associated conditions like plaques in the artery and metabolic syndrome, definitive proof is lacking that dietary factors influence lupus illness development or disease activity (Absher DM, 2013). Conflicting results are found with bound dietary factors, a number of which can have had supporting proof from animal models or case reports. Some studies have shown an association between vitamin D and lupus, however they're self-reported cases and that we would like a real bit of vitamin D in our body (limitation)(Costenbader KH,2008). We cannot accurately predict if vitamin D is related to SLE (Hiraki LT, 2012). Total antioxidant intake, as well as vitamins A, C, and E, α-carotene, β-carotene, β-cryptoxanthin, lycopene, lutein, and carotenoid, wasn't related to the chance of developing SLE (Costenbader KH, 2010). Silica was the sole exposure found to be related to lupus in three case management illness. Exposure to particulate silica (crystalline silica or quartz) most ordinarily comes from mining and “dusty trades” like sandblasting, granite cutting, construction work, cement work, brick and tile laying (Parks CG, 2002). The high dose exposure is related to the additional prevalence of the disease (Brown lm, 1997). Smoking is also one in every of the contributors. Smoking will have an effect on through genetic pathway and inflammatory reactor pathway (Costenbader KH, 2004). Epstein Barr Virus (EBV) that causes Infectious Mononucleosis(IM) shares clinical options with active lupus and leads to antinuclear antibody (ANA) positivity and production of SLE-related autoantibodies like anti-Sm (ANA and anti-Sm are the autoantibodies that we tend to use to see if the disease is