Synthesis of N, N-Dimethylbenzylamine

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Calcium Oscillations: Synthesis and Binding Studies of Photo-reversible Calcium Chelator

Harpreet Sandhanwalia December 2, 2011 Dr. Alison McCurdy

Abstract: Living bodies maintain a homeostasis by constant communication amongst the various cells and organs. Calcium plays a very important role in controlling this network of communication and henceforth helping in carrying out many essentials functions. However the exact working of Calcium signaling is yet to be studied and for that it requires synthesis of a molecule that would help mimic the cellular functioning in-vitro. Research is being conducted to form compound 2 and test its potential in regards with the previously created Photo-reversible Calcium Chelator, compound 1(a and b), naphthopyran 2,2’-(3,3-diphenyl-3H-benzo[f]chromen-5-ylazanediyl) diacetic acid. Introduction: Apart from being an essential component of bones, Calcium acts in many a different useful ways inside our bodies. And of all, the most important is its role in cell signaling. Calcium acts as a signal and most of the times as a second messenger, where it is released as a result of a signal and then triggers certain biological phenomenon within the cell. Calcium is stored in the Endoplasmic Reticulum and in the Mitochondria, and is also present outside the cell. A regular mechanism involving Calcium as a second messenger begins with some ligand binding to the receptor which activates the G-protein and causes the release of IP3 (inositol-1,4,5-triphosphate). IP3 interacts with the IP3 receptor located on the endoplasmic reticulum membrane and results in the release of Calcium through the same receptor linked ion-channel. Once in the cytoplasm, Calcium triggers many different mechanisms. One important role of Calcium, and rather calcium oscillations is in the process of fertilization. It has been noted that fusion of spermatozoa and the gamete leads to Calcium



References: 1. Kumar, S; Hernandez, D; Hoa, B.; Lee, Y.; Yang, J.; McCurdy, A. Org. Lett, 2008, 10, 3671-3764.Lester, H.A.; Nerbonne, J. Ann. Rev. Biophys. Bioeng., 1982, 11, 151-175. 2.

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