Synthesis Of Aspirin Lab Report
Synthesis of Aspirin (Acetylsalicylic Acid)
Abstract:
This experiment is about the synthesis of aspirin under laboratory conditions. Aspirin is prepared by reacting salicylic acid and acetic anhydride; in the presence of sulfuric acid. After fully dissolving the salicylic acid with acetic anhydride, the solution is cooled and cold water is then added. Once the crystals form they are then filtered and left to dry out. There mass is measured and recorded then the yield is calculated.
Introduction:
Purpose: The aim of this experiment is to synthesize the common pain killer aspirin through an esterification reaction between Salicylic Acid and Acetic Anhydride; using sulfuric acid as a catalyst (4).
Background:
Aspirin is one of the …show more content…
Weigh 50 grams of salicylic acid.
2. Measure 80 ml of acetic anhydride.
3. Transfer and mix the salicylic acid with acetic anhydride in an Erlenmeyer flask.
4. Add 0.5 ml of concentrated sulfuric acid.
5. Heat for 30 minutes at a temperature of 70o C, slowly stirring the mixture gently. Use the hot water bath under the fume hood, and insert a thermometer in the flask to monitor the temperature; make sure the temperature does not exceed 70o C.
6. Allow the flask to cool down to around 50o C.
7. Measure 750 ml of cold tap water.
8. Pour the cold water into the mixture.
9. Prepare a Buchner flask.
10. Insert the Buchner funnel into the flask; make sure the funnel is properly resting on the Buchner ring.
11. Place filter paper in the funnel.
12. Attach the vacuum pump to the flask.
13. Pour the contents of the mixture into the funnel.
14. Switch on the vacuum pump.
15. Transfer the crystals into a beaker, and let it dry.
16. Weigh the product.
17. Once the product is fully dry weigh it again, and record the measurement.
18. Prepare a capillary tube.
19. Take sample from the crystals using the capillary …show more content…
The solubility of drug indicates how fast it can enter the blood stream after ingestion (5). The general trend is, nevertheless, solubility increase as the temperature rises. However, in the case of medicinal drugs, a variety of thermodynamic and kinetics factors affect the dissolution of the drug: such as the activation energy required to drug to overcome the energy barrier. Another factor is temperature, but since the average human body temperature is around 37o C it is not regarded as an issue in this case
Abstract:
This experiment is about the synthesis of aspirin under laboratory conditions. Aspirin is prepared by reacting salicylic acid and acetic anhydride; in the presence of sulfuric acid. After fully dissolving the salicylic acid with acetic anhydride, the solution is cooled and cold water is then added. Once the crystals form they are then filtered and left to dry out. There mass is measured and recorded then the yield is calculated.
Introduction:
Purpose: The aim of this experiment is to synthesize the common pain killer aspirin through an esterification reaction between Salicylic Acid and Acetic Anhydride; using sulfuric acid as a catalyst (4).
Background:
Aspirin is one of the …show more content…
Weigh 50 grams of salicylic acid.
2. Measure 80 ml of acetic anhydride.
3. Transfer and mix the salicylic acid with acetic anhydride in an Erlenmeyer flask.
4. Add 0.5 ml of concentrated sulfuric acid.
5. Heat for 30 minutes at a temperature of 70o C, slowly stirring the mixture gently. Use the hot water bath under the fume hood, and insert a thermometer in the flask to monitor the temperature; make sure the temperature does not exceed 70o C.
6. Allow the flask to cool down to around 50o C.
7. Measure 750 ml of cold tap water.
8. Pour the cold water into the mixture.
9. Prepare a Buchner flask.
10. Insert the Buchner funnel into the flask; make sure the funnel is properly resting on the Buchner ring.
11. Place filter paper in the funnel.
12. Attach the vacuum pump to the flask.
13. Pour the contents of the mixture into the funnel.
14. Switch on the vacuum pump.
15. Transfer the crystals into a beaker, and let it dry.
16. Weigh the product.
17. Once the product is fully dry weigh it again, and record the measurement.
18. Prepare a capillary tube.
19. Take sample from the crystals using the capillary …show more content…
The solubility of drug indicates how fast it can enter the blood stream after ingestion (5). The general trend is, nevertheless, solubility increase as the temperature rises. However, in the case of medicinal drugs, a variety of thermodynamic and kinetics factors affect the dissolution of the drug: such as the activation energy required to drug to overcome the energy barrier. Another factor is temperature, but since the average human body temperature is around 37o C it is not regarded as an issue in this case