Streptokinase Research Paper
Where does it come from? (source? Natural or chemical)
Streptokinase is extracellular bacterial protein and it comes from purified strains of group C beta-hemolytic streptococcus. It hydrolyzes peptide bonds and has a non-protease plasminogen activator which activates plasminogen to plasmin. This enzyme is used through its lysine binding site which is used as a medical drug for patients with blood clots. It was originally discovered from a precipitate of salt, that was then purified so the active site was protected from the activation of streptokinase.
What do we use it in? Why? (Application)
Streptokinase is given to patients by one of two methods: intravenous or intracoronary. Both ways, it is given bolus to patients in a sodium chloride solution or a 5% Dextrose solution mixture in a maximum of 50 mL plastic container. The powdered Streptokinase must be completely mixed into a solution prior to being given to the patient. It should be given to the patient soon after the onset of symptoms.
Used when? Streptokinase is used when heart attack symptoms first present to improve the survival rates of patients. It can also be used for a variety of conditions to improve survival rate as well with conditions such as acute evolving transmural myocardial infarction, pulmonary …show more content…
What it does is it converts plasminogen to plasmin, which is an enzyme, to help dilute blood clots or arterial blockages which could lead to a heart attack. Streptokinase forms a 1:1 enzymatic ratio with the plasminogen that converts into plasmin. The plasmin breaks down fibrin clots and other plasma proteins which leads to the breakdown of blood clots. This is why it is essential to administer Streptokinase soon after the onset of symptoms, so the blood clot can be broken down before it results in a heart attack or any other life-threatening
Streptokinase is extracellular bacterial protein and it comes from purified strains of group C beta-hemolytic streptococcus. It hydrolyzes peptide bonds and has a non-protease plasminogen activator which activates plasminogen to plasmin. This enzyme is used through its lysine binding site which is used as a medical drug for patients with blood clots. It was originally discovered from a precipitate of salt, that was then purified so the active site was protected from the activation of streptokinase.
What do we use it in? Why? (Application)
Streptokinase is given to patients by one of two methods: intravenous or intracoronary. Both ways, it is given bolus to patients in a sodium chloride solution or a 5% Dextrose solution mixture in a maximum of 50 mL plastic container. The powdered Streptokinase must be completely mixed into a solution prior to being given to the patient. It should be given to the patient soon after the onset of symptoms.
Used when? Streptokinase is used when heart attack symptoms first present to improve the survival rates of patients. It can also be used for a variety of conditions to improve survival rate as well with conditions such as acute evolving transmural myocardial infarction, pulmonary …show more content…
What it does is it converts plasminogen to plasmin, which is an enzyme, to help dilute blood clots or arterial blockages which could lead to a heart attack. Streptokinase forms a 1:1 enzymatic ratio with the plasminogen that converts into plasmin. The plasmin breaks down fibrin clots and other plasma proteins which leads to the breakdown of blood clots. This is why it is essential to administer Streptokinase soon after the onset of symptoms, so the blood clot can be broken down before it results in a heart attack or any other life-threatening