Solubility and Test Tube
EXPERIMENT 5 - Preparation of Acetanilide
Preparation and purification of Acetanilide
[pic]
Purpose:
a) To synthesis acetanilide by reaction of aniline and acetic anhydride. b) To purify acetanilide by crystallization method from water c) Purity check by melting range
Equipment / Materials and Hazars:
hot plate beakers(150,250mL) ice stirring rod spatula
Büchner funnel aniline weighing paper digital scales rubber tubing (hose) acetic anhydride filter paper Mel-temp apparatus
10- mL graduated cylinder large test tube medicine dropper
| Compound | FW (g/mol) | MP (BP) | density | Hazards |
| Acetanilide | 135.17 | 114 ºC | --- | Irritant. Harmful if inhaled/ingested. |
| Aniline | 93.13 | (184 ºC) | 1.022 g/mL | Irritant (eyes/skin). Harmful if inhaled/ingested. Possible |
| | | | |carcinogen. |
| Acetic Anhydride | 102.09 | (138 ºC) | 1.082 g/mL | Irritant (eyes/skin). Toxic by inhilation, Flammable (fp 49 ºC). |
Discussion:
Recrystallization is a widely-used technique to purify a solid mixture. The desired product is isolated from its impurities by differences in solubility. Insoluble impurities and colored impurities can be removed from hot solvent through the use of activated carbon and filtration. Soluble impurities remain in the cold solvent after recrystallization. The desired product should be as soluble as
Preparation and purification of Acetanilide
[pic]
Purpose:
a) To synthesis acetanilide by reaction of aniline and acetic anhydride. b) To purify acetanilide by crystallization method from water c) Purity check by melting range
Equipment / Materials and Hazars:
hot plate beakers(150,250mL) ice stirring rod spatula
Büchner funnel aniline weighing paper digital scales rubber tubing (hose) acetic anhydride filter paper Mel-temp apparatus
10- mL graduated cylinder large test tube medicine dropper
| Compound | FW (g/mol) | MP (BP) | density | Hazards |
| Acetanilide | 135.17 | 114 ºC | --- | Irritant. Harmful if inhaled/ingested. |
| Aniline | 93.13 | (184 ºC) | 1.022 g/mL | Irritant (eyes/skin). Harmful if inhaled/ingested. Possible |
| | | | |carcinogen. |
| Acetic Anhydride | 102.09 | (138 ºC) | 1.082 g/mL | Irritant (eyes/skin). Toxic by inhilation, Flammable (fp 49 ºC). |
Discussion:
Recrystallization is a widely-used technique to purify a solid mixture. The desired product is isolated from its impurities by differences in solubility. Insoluble impurities and colored impurities can be removed from hot solvent through the use of activated carbon and filtration. Soluble impurities remain in the cold solvent after recrystallization. The desired product should be as soluble as