It has an important part in regulating mood and pleasure, both serving as a trigger for the synthesis of adrenaline and noradrenaline and acting as a neurotransmitter. When nicotine goes to the brain, it produces a rush of dopamine into the bloodstream, causing the user to become more relaxed and calm. In this respect, nicotine's chemical action is very similar to such other drugs as cocaine, amphetamines ,and morphine. In effect, each time a smokeless tobacco user puts a pinch of tobacco in his or her mouth or inhales some powder, he or she gets a powerfully reinforcing and rewarding chemical message from the brain that, over a short period of time, will cause physical and emotional dependence on tobacco. However, because the body quickly becomes used to nicotine through a process called "tolerance," users experience a gradual rise in the amount of tobacco they need to get the same physiological …show more content…
As of 1996, there were 30,000 new cases of oral cancer diagnosed in the United States, one-third of which were fatal. Some studies estimate that using smokeless tobacco raises the risk of oral cancer, which includes cancers of the throat, by as much as 50 percent. Smokeless tobacco use has also been strongly linked to cancers of the pancreas, nasal cavities, esophagus, pharynx (passageway for food and air), intestines, stomach, larynx ("voice box"), and urinary tract. Other no cancer health problems associated with smokeless tobacco include peptic ulcers, danger to fetuses, and damage of the salivary