Slow Hyponatremia Case Study
Central Pontine Myelinolysis in the setting of Slow Hyponatremia Correction
Wu, Alex M.D.1, Chen, Hsiong M.D.2, Harvin, Lisa D.O., M.S.3
1. Resident – Department of Medicine, Franklin Square Medical Center, MD
2. Neurology Hospitalist – Department of Neurology, Franklin Square Medical Center, MD
3. Resident – Department of Medicine, Franklin Square Medical Center, MD
Introduction
Central Pontine Myelinolysis is often a feared complication of overly aggressive correction of hyponatremia. As a result, close monitoring and slow correction are desired in order to prevent such neurological outcome. We describe a case in which an elderly gentleman, with a past medical history of CML and Polio, who was admitted to our hospital for generalized weakness, …show more content…
Adams RA, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients. Arch Neurol Psychiatry. 1959; 81(1): 154-172.
2. Graff-Radford, J, Fugate, JE, Kaufmann, TJ, Mandrekar, JN, and Rabinstein, AA. Mayo Clin Proc. 2011; 86(11): 1063-1067.
3. Greenberg A, Verbalis JG, Amin AN, Burst VR, Chiodo JA 3rd, Chiong JR, Dasta JF, Friend KE, Hauptman PJ, Peri A and Sigal SH. Kidney Int. 2015 Jul; 88(1): 167-77.
4. Martin, RJ. J Neurol Neurosurg Psychiatry 2004; 75(Suppl III): iii22–iii28.
5. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn E, Ichai C et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. European Journal of Endocrinology 2014; 170: G1–G47.
6. Staikov I, Simeonova A, Mihnev N, Simeonov G, Davidov K and Kirova G. Central Pontine Myelinolysis in Patient with Normal Serum Sodium Levels, System Alcohol Use and Malnutrition- A Case Report. Austin J Clin Neurol 2015; 2(9): 1074.
7. Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW and Sterns RH. Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations. Am J Med. 2007; 120: S1–S21.
8. Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH and Thompson CJ. Am J Med. 2013 Oct; 126(10 Suppl 1):
Wu, Alex M.D.1, Chen, Hsiong M.D.2, Harvin, Lisa D.O., M.S.3
1. Resident – Department of Medicine, Franklin Square Medical Center, MD
2. Neurology Hospitalist – Department of Neurology, Franklin Square Medical Center, MD
3. Resident – Department of Medicine, Franklin Square Medical Center, MD
Introduction
Central Pontine Myelinolysis is often a feared complication of overly aggressive correction of hyponatremia. As a result, close monitoring and slow correction are desired in order to prevent such neurological outcome. We describe a case in which an elderly gentleman, with a past medical history of CML and Polio, who was admitted to our hospital for generalized weakness, …show more content…
Adams RA, Victor M, Mancall EL. Central pontine myelinolysis: a hitherto undescribed disease occurring in alcoholics and malnourished patients. Arch Neurol Psychiatry. 1959; 81(1): 154-172.
2. Graff-Radford, J, Fugate, JE, Kaufmann, TJ, Mandrekar, JN, and Rabinstein, AA. Mayo Clin Proc. 2011; 86(11): 1063-1067.
3. Greenberg A, Verbalis JG, Amin AN, Burst VR, Chiodo JA 3rd, Chiong JR, Dasta JF, Friend KE, Hauptman PJ, Peri A and Sigal SH. Kidney Int. 2015 Jul; 88(1): 167-77.
4. Martin, RJ. J Neurol Neurosurg Psychiatry 2004; 75(Suppl III): iii22–iii28.
5. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn E, Ichai C et al. Clinical practice guideline on diagnosis and treatment of hyponatraemia. European Journal of Endocrinology 2014; 170: G1–G47.
6. Staikov I, Simeonova A, Mihnev N, Simeonov G, Davidov K and Kirova G. Central Pontine Myelinolysis in Patient with Normal Serum Sodium Levels, System Alcohol Use and Malnutrition- A Case Report. Austin J Clin Neurol 2015; 2(9): 1074.
7. Verbalis JG, Goldsmith SR, Greenberg A, Schrier RW and Sterns RH. Hyponatremia Treatment Guidelines 2007: Expert Panel Recommendations. Am J Med. 2007; 120: S1–S21.
8. Verbalis JG, Goldsmith SR, Greenberg A, Korzelius C, Schrier RW, Sterns RH and Thompson CJ. Am J Med. 2013 Oct; 126(10 Suppl 1):