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Sleep Disturbance and Melatonin Levels Following Traumatic Brain Injury

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Sleep Disturbance and Melatonin Levels Following Traumatic Brain Injury
Sleep disturbance and melatonin levels following traumatic brain injury J.A. Shekleton, D.L. Parcell, J.R. Redman, J. Phipps-Nelson, J.L. Ponsford and S.M.W. Rajaratnam Neurology 2010;74;1732-1738 DOI: 10.1212/WNL.0b013e3181e0438b

This information is current as of May 25, 2010

The online version of this article, along with updated information and services, is located on the World Wide Web at: http://www.neurology.org/cgi/content/full/74/21/1732

Neurology® is the official journal of the American Academy of Neurology. Published continuously since 1951, it is now a weekly with 48 issues per year. Copyright © 2010 by AAN Enterprises, Inc. All rights reserved. Print ISSN: 0028-3878. Online ISSN: 1526-632X.

Downloaded from www.neurology.org at WKH on May 25, 2010

Sleep disturbance and melatonin levels following traumatic brain injury

J.A. Shekleton, BBNSc (Hons) D.L. Parcell, DPsych J.R. Redman, PhD J. Phipps-Nelson, BBSc (Hons) J.L. Ponsford, PhD S.M.W. Rajaratnam, PhD

ABSTRACT

Objectives: Sleep disturbances commonly follow traumatic brain injury (TBI) and contribute to ongoing disability. However, there are no conclusive findings regarding specific changes to sleep quality and sleep architecture measured using polysomnography. Possible causes of the sleep disturbances include disruption of circadian regulation of sleep-wakefulness, psychological distress, and a neuronal response to injury. We investigated sleep-wake disturbances and their underlying mechanisms in a TBI patient sample.

Methods: This was an observational study comparing 23 patients with TBI (429.7 287.6 days post injury) and 23 age- and gender-matched healthy volunteers on polysomnographic sleep measures, salivary dim light melatonin onset (DLMO) time, and self-reported sleep quality, anxiety, and depression. Results: Patients with TBI reported higher anxiety and depressive symptoms and sleep disturbance than controls. Patients with TBI showed decreased sleep efficiency (SE)


References: 1. French J, Gronseth G. Lost in a jungle of evidence: we need a compass. Neurology 2008;71:1634 –1638. 2. Gronseth G, French J. Practice parameters and technology assessments: what they are, what they are not, and why you should care. Neurology 2008;71:1639 –1643. 3. Gross RA, Johnston KC. Levels of evidence: taking Neurology® to the next level. Neurology 2008;72:8 –10. 1738 NeurologyDownloaded 2010 www.neurology.org 74 May 25, from at WKH on May 25, 2010 Sleep disturbance and melatonin levels following traumatic brain injury J.A. Shekleton, D.L. Parcell, J.R. Redman, J. Phipps-Nelson, J.L. Ponsford and S.M.W. Rajaratnam Neurology 2010;74;1732-1738 DOI: 10.1212/WNL.0b013e3181e0438b This information is current as of May 25, 2010 Updated Information & Services Supplementary Material Subspecialty Collections including high-resolution figures, can be found at: http://www.neurology.org/cgi/content/full/74/21/1732 Supplementary material can be found at: http://www.neurology.org/cgi/content/full/74/21/1732/DC1 This article, along with others on similar topics, appears in the following collection(s): Depression http://www.neurology.org/cgi/collection/depression All Sleep Disorders http://www.neurology.org/cgi/collection/all_sleep_disorders Circadian rhythm sleep disorders http://www.neurology.org/cgi/collection/circadian_rhythm_sleep_ disorders Brain trauma http://www.neurology.org/cgi/collection/brain_trauma Information about reproducing this article in parts (figures, tables) or in its entirety can be found online at: http://www.neurology.org/misc/Permissions.shtml Information about ordering reprints can be found online: http://www.neurology.org/misc/reprints.shtml Permissions & Licensing Reprints Downloaded from www.neurology.org at WKH on May 25, 2010
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