Silkworm Ferritin Case Study

1.1. Silkworm (Bombyx mori) was described by Linnaeus in 1758 and belongs to the order Lepidoptera and the family Bombycidae. B. mori has been domesticated since last 5000 years ago in China, and used as a model system nearby a rich repertoire of in order connected in the genetic mutations to influence morphology, development, and behavior (Arunkumar et al., 2006). Furthermore a host of different pathogenic microorganisms. Different geographically differentiated genotypes, silk worm is the famous to show varying degree of tolerance to different pathogens (E.G.Abraham et al.,1995).Although earlier workers have characterized cecropin-like antibacterial proteins (Ravi, C et al.,2011) and lysozyme (powning and Davidson., 1973). Currently, the silkworm
Ferritin can play a key role in iron metabolism. The elements of Ferritin provide to restore capability during duel functions is iron storage and detoxification of iron overload into living cells. Insect ferritins are normally concerned into secretory pathways and circulate to different tissues throughout the hemolymphatic structure (Winzerling and Pham, 2006). study on the Structure of ferrtins that indicate the protein generally composed a 24-subunits hollow sphere complex that can contain and hold up to 4500 atoms of iron per molecule inside the protein shell, they are toxic yet and present into bio available formed, thought is a major iron storage protein of molecular level. It is universally circulated between living species, the majority also in mammals and insects, is composed of two kinds of subunits: called H- and L-type ( heavy-chain and light-chain,). Why they are Heavy chain and light-chain, because when see the mammalian H-type subunit include bigger molecular mass compared with L-type subunit).Generally the H-type subunit is characterized as preserved ferroxidase site that facilitates the quickly oxidation and uptake of ferrous iron, the L-type subunit facilitates the nucleation of the ferrihydrite iron core. (Xiaona Tang and Bing Zhou, 2013).A storage material of ferritin is the survival of functional forms of the both cytoplasmic as well as
(2007) and found the radio labeled of iron fed to A. aegypti in blood meal and were absorbed the iron transported near to the tissues, particularly in the ovaries and eggs, by secreted ferritin, an original technique of sequestering iron during infection is required to make sure the survival of the organism and to conciliation the possibility of the invading pathogen (Ganz, 2009; Ong et al., 2006; Weinberg & Miklossy, 2008; Wang & Cherayil, 2009). Scientist was also studying on the Ferritin in the invertebrates such as Daphnia pulex, Haliothis discuss, Macrobarchium rosenbergii, Branchiostoma belcheri, also a number of insects (Dawn L Geiser et al 2009). In 1988 early works by Hubebers et at; they were reported that iron loaded ferritin into larval hemolymph plus reproductive region of newly emerged female Manduca sexta (Dawn L Geiser et al 2009). In the Silk worm genome encodes have three types of ferittin. Such as Fer1HCH, Fer2LCH, and Fer3HCH. Interested our EST