Flea bites from rats would infect the Black Plague along merchants and consumers throughout Eurasia which caused a decline in the economy. During the Middle Ages ships would stop at various points such as Turkey, Lebanon, and Iraq that are along the Silk Road. People infected with the Black Plague would have bleeding under the skin, nervous system would collapse and eventually the deadly disease would lead to millions of death in both Asia and Europe. The Silk Road was closed off in 1346 completely to cease the spread of the Plague. Until it was reopened in 1350, the prices of goods were inflated since no trades were happening with the Silk Road being closed off. Even once the Road reopened it took approximately half a year until merchants would start buying spices, silk and jade again since everyone was unsure whether or not the deadly epidemic was truly gone.
After the Black Plague in 1353, China, India, Greece and Persia created a cultural bridge between Asia and Europe where China would focus more on religion due to a cessation with wars. Two of the biggest religion that changed the Silk Road was Buddhism and Islam. Buddhism spread during the Easter Han Dynasty era where the Kushan Kingdom promoted the religion which declares to block off hate, greed and delusion which are causes of suffering. This could of been the monks way to reassure the people of Eurasia that there doesn't have to be wars for a longer period of time if the people would escape through meditation. Besides, Buddhism, Islam is the Silk Road's biggest religion due to their relation with Muslim merchants. The merchants would follow the principles of life. It's very similar to Buddhism with how both religions promote peace however, Islam