Preview

Sickle Beta Thalassemia Research Paper

Satisfactory Essays
Open Document
Open Document
79 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Sickle Beta Thalassemia Research Paper
Sickle beta thalassemia carry oxygen, O2 to different part of body. this is an inherited condition. It causes decreasing of the production the hemoglobin which depends on the beta thalassemia mutation. That person does not have normal blood cells. This results in placing of hydrophobic amino acid valine in place of hydrophilic amino acid glutamic acid, at the sixth amino acid postion. Sickle cell anemia has a high mortality rate. Sickle cell anemia is also a very critical

You May Also Find These Documents Helpful

  • Good Essays

    A change or mutation in the amino acid sequence may cause the protein to not carry out its function in the cell. If the wrong amino acid is present in the sequence, a malfunction can take place, such as sickle cell anemia.…

    • 565 Words
    • 3 Pages
    Good Essays
  • Powerful Essays

    Physioex Case Study

    • 1117 Words
    • 5 Pages

    Why do you think that it has this effect? Hint: Sickle cell anemia alters the shape of red blood cells. The hemoglobin takes on an irregular shape that alters the shape of the red blood cells. They change from round (which is normal), to a shape of a doughnut, to the extended shape of a sickle. Sickle cells are pointed and rigid, not like that of normal red blood cells that move effortlessly through the small blood vessels. Sickle cells are apt to get caught in narrow blood vessels which in turn obstructs the progression of blood. Sickle cells have a shorter life span that eventually causes anemia due to the low RBC count. Norman red blood cells survive for 120 days in flow—sickle cells survive only 10 to 20…

    • 1117 Words
    • 5 Pages
    Powerful Essays
  • Good Essays

    1. Sickle cell disease is a group of disorders that affects hemoglobin, the molecule in red blood cells that delivers oxygen to cells throughout the body. People with this disorder have atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape.…

    • 819 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Bilogy 3 Research Paper

    • 921 Words
    • 4 Pages

    Sickle cell anemia affects people with African, Mediterranean, Middle Eastern, and Indian ancestry (Scientific American). Sickle cell anemia occurs when a person inherits two sickle cell gene, one from each parent, that cause the red blood cells to change and become crescent shaped. The underlying problem involves hemoglobin, a component of the red blood cells. Hemoglobin is a protein molecule in red blood cells that carries oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues to the lung. In sickle cell anemia, the hemoglobin is flawed (The New York Times). As a result, the cells become sickle shaped and can’t travel as easily through blood vessels. Sickle cell anemia is an illness, which has one primary cause, but a variety of symptoms and treatments (Scientific American.) Like some illnesses, sickle cell anemia has one primary cause. In order for sickle cell anemia to occur is when a sickle cell gene have, been inherited from both the mother and the father, so that the child has two sickle cell gene. The sickle cell gene causes the body to make abnormal hemoglobin. As mentioned above, hemoglobin is a protein molecule in red blood cells that carries oxygen from the lungs to the body’s tissues and returns carbon dioxide from the tissues to the lungs. A person with normal red blood cell will have hemoglobin A; however, a person with sickle cell disease will have hemoglobin S…

    • 921 Words
    • 4 Pages
    Good Essays
  • Satisfactory Essays

    Sickle Cell Plan of Care

    • 610 Words
    • 2 Pages

    Sickle cell anemia is the most common form of sickle cell disease which is an inherited, autosomal recessive disorder that causes an abnormal hemoglobin cell. The person with this specific disorder inherited hemoglobin S from both parents, also known as homozygous (Lewis, Dirksen, Heitkemper, & Bucher, 2014, pp. 644-647). This hemoglobin S results from the substitution of valine for glutamic acid on the B-globin chain of hemoglobin, and this ultimately causes the erythrocyte to stiffen and elongate taking a sickle shape in response to low oxygen levels (Lewis et al., 2014, pp. 644-647). Due to the sickle cells elongated shape, and its stiff and sticky consistency it tends to get stuck in capillaries and vessels, and blocks blood flow to limbs and organs (Lewis et al., 2014, pp. 644-647). The major problems with sickle cell anemia is due to their sickled shape, reduced life expectancy and their ability to carry enough hemoglobin or transport it properly to…

    • 610 Words
    • 2 Pages
    Satisfactory Essays
  • Satisfactory Essays

    Genetic Disease 4

    • 373 Words
    • 4 Pages

    Sickle cell disease is a autosomal recessive trait that occurs due to the single base substitution in DNA.…

    • 373 Words
    • 4 Pages
    Satisfactory Essays
  • Good Essays

    Sickle-Cell Anemia

    • 1625 Words
    • 7 Pages

    Sickle-cell disease is a genetic disorder that results from the abnormal structure of red blood cells. The peculiar shape of the red blood cell prevents the normal absorption of oxygen. This disease results from the abnormal production of hemoglobin S (HbS). Therefore, a mutation in this gene causes a lower supply of oxygen to the cells, which results in occlusion of the blood vessels. Individuals diagnosed with sickle-cell anemia have abnormal function of the gene that encodes for subunit B, which is a protein that serves as part of the hemoglobin A (HbA). The HbA is responsible for oxygen binding through the blood stream. Indeed, the abnormal polymerization of hemoglobin occurs in homozygous individuals with sickle-cell anemia, which lowers the oxygen supply of red blood cells. To lower the negative consequences of sickle-cell anemia, it is necessary to provide a better understanding of the genetic material that underlies the sub-phenotype of sickle-cell anemia. Therefore, this could help in the discovery of drugs that could target the genes responsible for sickle-cell anemia.…

    • 1625 Words
    • 7 Pages
    Good Essays
  • Powerful Essays

    Sickle Cell Anemia

    • 1567 Words
    • 5 Pages

    Sickle cell anemia or also known as sickle cell disease is a hereditary genetic disease defined by the presence of odd shaped crescent-shaped red blood cells instead of the regular round disc like shape cells. Red blood cells transport oxygen from the lungs to various other organs and tissues with the help of a protein called hemoglobin. The main cause of sickle cell disease is when hemoglobin mutates into an abnormal type called hemoglobin S. The presence of Hemoglobin S causes red blood cells to be sickle-shaped and rigid, making it more difficult for them to flow through blood vessels in the body to deliver oxygen. Therefore, the sickled cells latch onto the walls of various blood vessels throughout the body, resulting in blocked blood flow that can lead to organ damage, pain and infections…

    • 1567 Words
    • 5 Pages
    Powerful Essays
  • Satisfactory Essays

    Cystic Fibrosis

    • 303 Words
    • 1 Page

    Sickle-cell disease is caused by a single point mutation in the beta-hemoglobin gene that converts a GAG codon into GUG, which encodes the amino acid valine rather than glutamic acid. Tay - Sachs disease is an autosomal recessive genetic disorder caused by a genetic defect in a single gene with one defective copy of that gene inherited from each parent. This disease occurs when harmful quantities of gangliosides accumulate in the nerve cells of the brain, eventually leading to the premature death of those cells.…

    • 303 Words
    • 1 Page
    Satisfactory Essays
  • Good Essays

    Sickle Cell Anemia

    • 568 Words
    • 4 Pages

    the supply of oxygen gets cut off. A normal blood cell lives up to 120…

    • 568 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Sickle Cell Anemia

    • 1657 Words
    • 7 Pages

    Sickle Cell Anemia, also known as Sickle Cell Disease, is a disease that causes the production of abnormal hemoglobin. The red blood cells (RBCs) carry oxygen to organs and tissues. Hemoglobin, a molecule in the RBCs, is a protein that attaches to the oxygen in the lungs and carries it to all parts of the body. Hemoglobin takes on the oxygen, and releases carbon dioxide, a process known as oxygenation. In the tissues, deoxygenation occurs where the processes is reversed, when hemoglobin releases oxygen and takes on carbon dioxide. When the RBCs are healthy, they can easily move through the tiniest blood vessels throughout the body because of their flexibility. The hemoglobin S is fragile and abnormal in Sickle Cell Anemia, and the RBCs are pointy with a shape like the alphabet letter "C" or the crescent moon. This makes the RBCs difficult to move pass through the blood vessels. The RBCs become hard, and can get stuck in blood vessels, and often clog the spleen. This causes pain, infection, and poor blood flow in patients that have Sickle Cell Anemia. The RBCs also block blood flow to organs, such as the heart, lungs, brain, etc., which can lead to stroke, damage to organs, especially the spleen, acute chest syndrome, disability, and sometimes, even death.…

    • 1657 Words
    • 7 Pages
    Good Essays
  • Good Essays

    Sickle Cell Anemia

    • 1001 Words
    • 5 Pages

    Sickle cell disease is an autosomal recessive genetic disorder most common in African Americans, which results from a mutation affecting the amino acid sequence of the beta chains of hemoglobin molecules in red blood cells. The abnormal hemoglobin which causes the red blood cells to sickle is called hemoglobin S. Sickling occurs when the red blood cells are deoxygenated causing the cell to have a hard curved crescent shape. Due to their shape the sickle cells can become trapped in blood vessel walls causing a circulatory blockage and could cause tissues to become oxygen deprived, pain, infection, and organ damage. Red blood cells in sickle cell disease also have a life span of 10 to 20 days compared to normal red blood cells of 120 days; because of this shortened life span chronic hemolytic anemia occurs (Thompson, 2012). All together sickle cells disease causes a dramatic decrease in the quality of life that can lead to early death, the absolute need for medical intervention, and transplantations.…

    • 1001 Words
    • 5 Pages
    Good Essays
  • Good Essays

    Sickle Cell Anemia (SDA)

    • 1296 Words
    • 6 Pages

    Sickle cell anemia (SCA) also known as sickle-cell disease (SDA) is the most common genetic blood disorder that most people know far to little about. It is blood disease identified by abnormal looking red blood cells (Primary Health Care 2012). Normal blood cells tend to be soft and round and travel to through the body smoothly as for sickle cells, on the other hand, look like a hard falcate moon shape (Primary Health Care 2012). These abnormal red blood cells result in a difficult blood flow of oxygen throughout the body (Connecticut Department of Public Health 2008). This disease can be life threatening. Sickle cells can cause clogged blood vessels and result in damaged organs or even a stroke. In addition, sickle cells are more susceptible…

    • 1296 Words
    • 6 Pages
    Good Essays
  • Good Essays

    The Sickle Cell Crisis

    • 547 Words
    • 3 Pages

    Therefore, provision of optimal care plans and effective treatments for patients with sickle cell anemia must cumulate more research and funding. A large issue with the type of aid offered to sickle cell patients comes from the lack of treatment and medicines that are made available to patients. Painful attacks sickle crisis are things patients with SCD are subject to regularly. Crisis tend to render sickle cell patients immobile for large periods of time with intense sharp pains to the joints muscles and head. A sickle cell crisis occurs because of the accumulation of red blood cells in the blood stream causing a blockage. This block causes restricted flow of blood towards the rest of the body. Studies have shown that because the available treatment for sickle cell is limited and the availability of treatment medications are scarce, the population of people suffering from SCD are left medically neglected, prompting the need for more research and fund allocation towards sickle cell research even more evident. In a study performed by “the National Heart, Lung, and Blood Institute over the effectiveness of Hydroxyurea in treating SCD, showed that there was a noticeable decrease in their attacks, and a 40% reduction in mortality” (Halsey…

    • 547 Words
    • 3 Pages
    Good Essays
  • Powerful Essays

    Anemia In America

    • 5138 Words
    • 21 Pages

    Anemia is the most common blood disorder currently affecting more than 3 million Americans and over 2 billion people globally. Although many cases of anemia are mild, it can drastically reduce the amount of oxygen transported in the blood. This can cause the individual to feel fatigue and to have a diminished capacity to do any type of physical activity. The more severe forms of anemia are also known to cause shortness of breath and reduce endurance in individuals due to the vast reduction of the red blood cells’ ability to carry oxygen from the lungs. When left untreated or undiagnosed, anemia can cause severe problems and can lead to secondary organ dysfunctions such as heart failure, cancer and liver problems. More severe forms of anemia such as thalassemia, pernicious anemia and sickle-cell are life threatening bring forth devastating results. Anemia is one of the few conditions that does not discriminate in sizes, it affects individuals from birth to death. However different forms of anemia affect people…

    • 5138 Words
    • 21 Pages
    Powerful Essays