Serum Sickness

Topics: Lymphatic system, Inflammation, Blood, Immune system / Pages: 2 (358 words) / Published: Jul 23rd, 2013
Hives (urticaria) and edema about the mouth and eyelids were the first symptoms of serum sickness developed by Gregory. What caused these early symptoms? * activation of complement-generated c3a which in turn caused the mass cells to release histamine from mast cells. * hives otherwise known as urticaria. * The oedema around the mouth and eyelids were observed as a result of angiodema. * This swelling often results from the same inflammatory processes that cause hives.

At one point Gregory became confused and disoriented and did not recognize his parents. His cerebrospinal fluid was normal and a CT scan of his brain was normal. However, an electroencephalogram displayed an abnormal pattern of brain waves. What produced these clinical and laboratory findings? * vasculitis in the small vessels * Vasulitis is basically a group of disorders that destroy blood vessels by inflammation. * Therefore the oxygen delivery to gregorys brain was compromised leaving him in a state of confusion, disorientation and the disability of not being able to recognise his parents.

Other laboratory findings from blood tests along with the effects on his feet and ankles help to confirm what the effects on the brain suggested. Explain what is occurring immunologically to generate the effects? * Again, vasculitis had occurred. * Purpura on his feet which indicates some form of hemorrahage. * Consequently, small blood vessals in the skin are blocked with clots. * The immunofluorescence showed also showed deposition of IgG and C3 in the perivascular areas which as a result generates the immunological effects.

Gregory had enlarged lymph nodes everywhere and his spleen was also enlarged. If you had a biopsy of a node what would you expect to see? * If one was to have a biopsy of a node then they could expect to a vast amount of plasma cells in the medulla of the brain. * Along with this, follicular hyperplasia and

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