Serum Creatinine Concentration Paper

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Serum creatinine concentration shows a relationship with GFR, making it specific, but not a sensitive measure of GFR. The creatinine pool is influenced by nutritional state, hepatic disease gender, ethnicity, protein intake, and age (Slack et al., 2010).
In liver cirrhosis, the decrease in serum creatinine is due to a 50% reduction in hepatic production of creatine; increases in volume of distribution due to accumulation of extracellular fluid, ascites, edema, loss of muscle mass and malnutrition, which is related to recurrent states of sepsis and large volume of ascites influencing satiety (Slack et al., 2010). Moreover, patients with liver cirrhosis have a significant lower baseline serum creatinine concentration than the population (35–75
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The result is multiplied by a constant of 0.85 in females. This formula is helpful due to simple calculation.
Serum creatinine measured in µmol/L: Where Constant is 1.23 in men and 1.04 in
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This is known as (HRS) which, in the late stages of hepatic disease, can result in extensive renal vasoconstriction and a marked decrease in GFR.
In the early stages of hepatic disease, systemic and renal hemodynamic variations are found while kidney function tests are normal. The dynamic monitoring of haemodynamic changes in the kidney are important for determining renal blood flow and predicting the development of HRS in patients with chronic liver disease and portal hypertension (Wang et al., 2011).
Duplex Doppler waveform analysis of intra-renal arterial vessels resembles a noninvasive method of determining reno vascular resistance. Particularly , the renal arterial resistive index (RI) can be evaluated from the ultrasonography and is a measure of resistance to arterial flow within the renal vessels that has been considered an accurate indicator of renal blood flow in different pathological states (Wang et al., 2011). Fig. (2): Normal RI Imaging (Viazzi et al.,

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