SCID

Topics: Immune system, Lymphocyte, Antibody Pages: 3 (1974 words) Published: October 26, 2014

Jessica Addai
Madhu UmashankarPd.8
AP Biology Final
Severe Combined Immunodeficiency (SCID)
Severe combined immunodeficiency also known as SCID is a rare inherited immunodeficiency disorder which is caused by defects in one’s genes. SCID exposes life threatening infection through dangerous viruses, bacteria, and fungi to the human body which could possibly lead to death or permanent harm to one’s health. SCID is therefore known as the "boy in the bubble" syndrome because through the possibilities of exposure to different fatal infections, the immunodeficiency disorder has the ability to restrict one from direct contact with his or her environment, causing isolation to occur. Due to simple everyday environmental factors such as germs, could pose a serious risk for fatal infections to take action in a person with SCID. Through historical aspects, SCID was first discovered in Switzerland by Glanzmann and Riniker in 1950 through Swiss infants who died of the disorder before their first birthday due to exposure of an infection. In 1972, the first molecular cause of human SCID was discovered, adenosine deaminase deficiency (ADA- SCID). There are numerous types of SCID such as: X-linked severe combined immunodeficiency, Adenosine deaminase deficiency, Purine nucleoside phosphorylase deficiency, Reticular dysgenesis, etc. Through better sources of knowledge such as advances in molecular biology and the Human Genome project, there is a rise in understanding on how this disease came to be. Even after the discovery, the rare disease wasn’t really known to much of humanity till the portrayal of the movie “The Boy in the Plastic Bubble” which displayed a story of a boy born with SCID in which he had to live in a plastic bubble in order to protect himself from infections; the movie demonstrated how some infections that don’t really harm someone without SCID can have a huge impact on someone with SCID. Though there are no specific records, SCID affects about 40-100...

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