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Role Of Neural Degeneration In Huntington's Disease

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Role Of Neural Degeneration In Huntington's Disease
Huntington’s disease (HD) is an autosomal dominant neurodegenerative disease for which there are currently no treatments that slow or halt its progression(1) The cardinal early features of the disease are movement disorders, including chorea and incoordination, and later on, dystonia,rigidity, and bradykinesia become more prominent.Patients die usually between 15 and 25 years after development of the first symptoms.(2,3,4) Brains from patients with HD show neuronal degeneration,most prominently in the striatum. The mechanism of neuronal degeneration is uncertainbut mitochondrial dysfunction may be one of the importantcontributors to neuronal dysfunction and finally neurodegeneration in HD.(5-7) Ethyl-eicosapentaenoate (ethyl-EPA) is a semisynthetic,highly
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