Research Paper On Trans-Resveratrol
Trans-resveratrol has long been known to exhibit antioxidant properties owing to the presence of three hydroxyl group which can readily scavenge any free radical either by donating a hydrogen atom or by forming a non radical product with the radical. Reactive oxygen species (ROS) and reactive nitrogen species (RNS), the most potent of free radicals have been shown to be involved in initiation of heart and cancer related diseases by damaging DNA and other macromolecules in the body. It is associated with a surprising number of health benefits. Lipid peroxidation is considered as one of the basic mechanism involved in tissue damage induced by a free radical source producing lipid peroxide radicals. Fig 1 trans-resveratrol
trans-resveratrol …show more content…
In vivo, it activates naturally occurring antioxidative enzymes Superoxide dismutase (SOD) to fight oxidative stress. trans-resveratrol would combat this oxidative stress either by neutralizing these free radicals or by repairing damage. trans-resveratrol can neutralize these free radicals by donating an electron or hydrogen atom and itself forming a phenoxy radical which is stabilized by resonance. It is believed that continuous attack of these free radicals on membranes, lipids and other biomolecules is the major reason of tissue damage and hence many diseases resulting in ageing. Thus in this regard trans-resveratrol could prove a great asset to human kind. There is a famous French paradox according to which people in France, in spite of having high fat diet suffer less from coronary heart diseases (CHD) as they take a large amount …show more content…
Resveratrol is supposed to correct the redox imbalance as in redox status i.e. oxidized (glutathione)/reduced (glutathione). The delicate balance between beneficial and harmful effect of free radicals is a very important aspect of living organisms and is achieved by mechanism called redox regulation (Kroon et al., 2010).
The various mechanisms by which an antioxidant can scavenge the free radicals have already been discussed in previous chapter. In this work, we will try to explain which mechanism is dominant for a particular radical qualitatively. The contribution of different mechanism depends upon the ability of the solvent to ionize the molecule and the reduction potential of the radical ions
trans-resveratrol …show more content…
In vivo, it activates naturally occurring antioxidative enzymes Superoxide dismutase (SOD) to fight oxidative stress. trans-resveratrol would combat this oxidative stress either by neutralizing these free radicals or by repairing damage. trans-resveratrol can neutralize these free radicals by donating an electron or hydrogen atom and itself forming a phenoxy radical which is stabilized by resonance. It is believed that continuous attack of these free radicals on membranes, lipids and other biomolecules is the major reason of tissue damage and hence many diseases resulting in ageing. Thus in this regard trans-resveratrol could prove a great asset to human kind. There is a famous French paradox according to which people in France, in spite of having high fat diet suffer less from coronary heart diseases (CHD) as they take a large amount …show more content…
Resveratrol is supposed to correct the redox imbalance as in redox status i.e. oxidized (glutathione)/reduced (glutathione). The delicate balance between beneficial and harmful effect of free radicals is a very important aspect of living organisms and is achieved by mechanism called redox regulation (Kroon et al., 2010).
The various mechanisms by which an antioxidant can scavenge the free radicals have already been discussed in previous chapter. In this work, we will try to explain which mechanism is dominant for a particular radical qualitatively. The contribution of different mechanism depends upon the ability of the solvent to ionize the molecule and the reduction potential of the radical ions