Research Paper On Abilify-Drugs
Problems and Solutions Drug Research Report
David Jaime
Health Careers High School
Abstract
The first drug that I am researching is Abilify or the generic name aripiprazole. Aripiprazole was first approved by the Food and Drug Administration on November 15, 2002 as a atypical antipsychotic. RxLists (2015) states the “empirical formula to be C23H27Cl2N3O2”. http://www.rxlist.com/abilify-drug.htm Abilify can be administered orally or injected(parenteral). Via the oral route Abilify can come as a tablet or a solution. Through the parenteral route it is injected intravenously. Abilify’s mechanism of action or the way it works is it is a partial agonists that binds to D2 and 5-HT1A receptors. When these are activated they are the ones that …show more content…
Abilify's absorption is described as “the absolute oral bioavailability of the tablet formulation is 87%” according to RxList(2015) and the peak level or highest concentration in the bloodstream occurs within 3 to 5 hours. Its distribution according to eMC(2009) includes “widely distributed throughout the body with an apparent volume of distribution of 4.9 l/kg”. Abilify is metabolized by three biotransformation pathways, dehydrogenation, hydroxylation, and N-dealkylation. The dehydrogenation and hydroxylation are catalyzed by CYP3A4 and CYP2D6 while N-dealkylation is catalyzed by CYP3A4. According to dailyMed.com Abilify’s excretion or elimination is “75 hours and 146 hours for aripiprazole in EMs and PMs, respectively”. For the most part there are no special populations that will change the dosage of abilify. This means that neither age, gender, or ethnic/race will affect the amount of dosage required to treat the disorder. In a clinical study of the effects of Abilify on pediatric patients with schizophrenia revealed that the 30 mg dose had the same effect as the 10 mg affect long termly. The
David Jaime
Health Careers High School
Abstract
The first drug that I am researching is Abilify or the generic name aripiprazole. Aripiprazole was first approved by the Food and Drug Administration on November 15, 2002 as a atypical antipsychotic. RxLists (2015) states the “empirical formula to be C23H27Cl2N3O2”. http://www.rxlist.com/abilify-drug.htm Abilify can be administered orally or injected(parenteral). Via the oral route Abilify can come as a tablet or a solution. Through the parenteral route it is injected intravenously. Abilify’s mechanism of action or the way it works is it is a partial agonists that binds to D2 and 5-HT1A receptors. When these are activated they are the ones that …show more content…
Abilify's absorption is described as “the absolute oral bioavailability of the tablet formulation is 87%” according to RxList(2015) and the peak level or highest concentration in the bloodstream occurs within 3 to 5 hours. Its distribution according to eMC(2009) includes “widely distributed throughout the body with an apparent volume of distribution of 4.9 l/kg”. Abilify is metabolized by three biotransformation pathways, dehydrogenation, hydroxylation, and N-dealkylation. The dehydrogenation and hydroxylation are catalyzed by CYP3A4 and CYP2D6 while N-dealkylation is catalyzed by CYP3A4. According to dailyMed.com Abilify’s excretion or elimination is “75 hours and 146 hours for aripiprazole in EMs and PMs, respectively”. For the most part there are no special populations that will change the dosage of abilify. This means that neither age, gender, or ethnic/race will affect the amount of dosage required to treat the disorder. In a clinical study of the effects of Abilify on pediatric patients with schizophrenia revealed that the 30 mg dose had the same effect as the 10 mg affect long termly. The