Regeneration In The PNS Essay

Regeneration in the adult nervous system is limited compared with other tissues. This limitation is due to the lack of proliferation and regeneration of neurons to accomplish correct connections.
A key difference between the PNS and CNS is the capacity for peripheral nerves to regenerate. Regeneration in the PNS is more successful due to the presence of Schwann cells (SCs), which provide nutrients, guide and myelinate the peripheral axons and synthesize growth factors. Moreover, the bands of Büngner in the PNS, which are clusters of oriented SCs, remain after the injury facilitating its regeneration.

The CNS is a greater challenge for new therapies, because the CNS axons do not regenerate appreciably in their native environment. Neural tissue