Preview

Refractory Hematological Malignancies Innovative Drug Market - Therapeutic Class Overview

Powerful Essays
Open Document
Open Document
712 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Refractory Hematological Malignancies Innovative Drug Market - Therapeutic Class Overview
Targeting unmet needs in the treatment of cancer/ hematological malignancies through innovative drug development strategies have witnessed favorable outcomes. Over the past decade, Proteasome inhibitor, Velcade (bortezomib) and the immunomodulatory drugs – Thalomid (thalidomide) and Revlimid (lenalidomide) have become the cornerstone of treatment for patients with Multiple Myeloma (MM) resulting in improved survival. However, eventually all patients relapse and new treatment options for Relapsed/ Refractory Multiple Myeloma (RRMM) are required to further improve survival and quality of life of this group of pts. Two new drugs have successfully fulfilled this need – POMALYST/ IMNOVID (pomalidomide – POM) and Kyprolis (carfilzomib-CFZ) but is there room for more?
We expect a similar scenario to unfold in the treatment of Recurrent/ Refractory MDS (RR-MDS, High-Risk MDS), and Relapsed/ Refractory AML (R/R AML). Innovative approach to treating unmet need has been handsomely rewarded in the past through in-licensing or outright acquisition of the mature/nascent product/innovator company at a premium. The report provides an overview of the approved therapies for RRMM, NDMM, AML, MDS, unmet need and limitations of the current SOC for relapsed and refractory pts. The report highlights the competition and commercial opportunity in pursuing these therapy areas – Comprehensive list of the early and late stage drugs in the clinic, their MoA and the companies developing them

Request Sample for this Report @ http://www.reportsnreports.com/contacts/RequestSample.aspx?name=275198 .

Multiple Myeloma (MM): New Treatment Options Driving In-Licensing and M&A
Table of Contents
1. Executive Summary 3
2. Disease Overview 4
3. Current Standard of Care 5
1. Relapsed and/or Refractory Multiple Myeloma
2. Newly Diagnosed Multiple Myeloma
4. Approved Products 11-20
1. Revlimid (lenalidomide) lzomib)2. Kyprolis (car
3. POMALYST / IMNOVID (pomalidomide)

Complete

You May Also Find These Documents Helpful

  • Powerful Essays

    Bortezomib And Irinotecan

    • 1511 Words
    • 7 Pages

    Following phase II clinical trials, bortezomib was approved on May 13, 2003 by the US…

    • 1511 Words
    • 7 Pages
    Powerful Essays
  • Satisfactory Essays

    Glioma is the most common primary brain tumor [1, 2] and it is one of the most rapidly growing, therapy resistant and devastating cancers [3]. High-grade glioma patient’s prognosis is very poor [4, 5] and the median survival is only 14.6 months after receiving all the currently available treatments [1]. A new effective therapeutic approach is urgently needed to give some hope to the glioma patients.…

    • 70 Words
    • 1 Page
    Satisfactory Essays
  • Good Essays

    Stick to the treatment plans and go for regular check-ups so as to monitor the progress of the…

    • 1155 Words
    • 5 Pages
    Good Essays
  • Good Essays

    Over past few years, Arena Pharmaceuticals has restructured and rebuilt their organization. Long known as a weight loss company, Arena has shed its former image to focus on their proprietary clinical stage pipeline. In addition to ralinepag, Arena Pharmaceutical’s proprietary pipeline portfolio includes two other drugs: Etrasimod (APD334) and APD371. Etrasimod (APD334), a next generation S1P receptor modulator, is currently in multiple Phase 2 trials for autoimmune diseases. Results from Phase 2 trial in ulcerative colitis is expected by the end of the year. Unlike first generation receptor modulators, APD334 is selective in which receptors are targeted. In earlier studies, ADP334 has demonstrated significant lymphocyte reduction and a positive safety profile.…

    • 618 Words
    • 3 Pages
    Good Essays
  • Satisfactory Essays

    Multiple Myeloma is formed by the development of abnormal plasma cells in the bone marrow and it is a type of cancer too much bone concern in the body. This type of cancer can cause death if not treated. The most common symptoms of anemia and bone pains. Diagnosed with cancer patients as for therapeutic purposes; Chemoterapy, Corticosteroid, Stem Cell Transplant etc. methods are used. These are common and reliable treatment methods for Multiple Myeloma. Visible improvement of %80, when viewed in the correct treatment methods. Nowadays, continues investigating try to find a reliable treatment methods for Multiple…

    • 99 Words
    • 1 Page
    Satisfactory Essays
  • Powerful Essays

    Multiple Sclerosis

    • 2125 Words
    • 9 Pages

    Multiple sclerosis [MS] is a chronic, autoimmune, inflammatory, neurodegenerative condition of the central nervous system [CNS] (Boppanna, Huang, Ito & Dhib-Jalbut, 2011) characterized by demyelination and axonal loss (Chastain, Duncan, Rodgers & Miller, 2011). MS expresses itself in 4 forms: relapsing remitting MS [RRMS], secondary progressive MS [SPMS], primary progressive MS [PPMS], and progressive relapsing MS [PRMS] (Boppanna, Huang, Ito & Dhib-Jalbut, 2011). MS affects 0.1 per cent of the world’s population (Chastain, Duncan, Rodgers & Miller, 2011), occurring 2- and 2.5-fold more frequently in women than in men, having an incidence range of post-pubertal teenagers to adults in their 50’s (Calabresi, 2011).…

    • 2125 Words
    • 9 Pages
    Powerful Essays
  • Satisfactory Essays

    Chronic Myeloid Leukemia

    • 380 Words
    • 2 Pages

    Chronic myelogenous (or myeloid) leukemia (CML), also known as chronic granulocytic leukemia (CGL), is a cancer of the white blood cells. It is a form of blood cancer characterized by the increased and unregulated growth of predominantly myeloid cells in the bone marrow and the accumulation of these cells in the blood. CML is a clonal bone marrow stem cell disorder in which proliferation of mature granulocytes (neutrophils, eosinophils, and basophils) and their precursors is the main finding. It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome. CML is now largely treated with tyrosine kinase inhibitors (TKIs), such as imatinib, dasatinib, or nilotinib, which have led to dramatically improved survival rates since their introduction in the last decade.…

    • 380 Words
    • 2 Pages
    Satisfactory Essays
  • Better Essays

    Multiple Myeloma

    • 2211 Words
    • 9 Pages

    Multiple Myeloma is a form of cancer which affects the plasma cells of the body, which are white blood cells. Multiple Myeloma, first described in 1848, is a disease “characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein.” To understand how Multiple Myeloma affects an infected person’s plasma cells, it helps to have a general understanding of how normal blood cells are formed and how they act. Most blood cells develop from stem cells, which can be found in bone marrow (soft material inside our bones – the “filling”). Stem cells mature into white blood cells, red blood cells, or platelets.2 The purpose of white blood cells is to fight off infection, while red blood cells carry oxygen and platelets aid in blood clotting, which controls bleeding. Plasma cells make antibodies, which are parts of the immune system and help the body protect itself from germs and other harmful substances (Exhibit 1).2…

    • 2211 Words
    • 9 Pages
    Better Essays
  • Satisfactory Essays

    The acute ischemic stroke (AIS) market is poised for major changes during the forecast window out to 2017. Given the impending patent expiry of Activase/Actilyse, in 2015 and 2016 in the US and 5EU respectively, the current standard of care for AIS patients is expected to lose its leading position. From 2015 onwards, Activase is expected to see declining sales; this is not only attributed to loss of patent protection, and the subsequent erosion from potential biosimilar versions, but is largely a result of the anticipated launch of Lundbecks desmoteplase in 2015.…

    • 462 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    These principles have been prepared as an aid to those who have initiated or are…

    • 1178 Words
    • 5 Pages
    Good Essays
  • Better Essays

    Targeted Cancer Therapy

    • 1137 Words
    • 5 Pages

    Advances in the knowledge of molecular biology of cancer and pathways involved in malignant transformation of cells are revolutionizing the approach to cancer treatment with a focus on targeted cancer therapy. Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules involved in cancer growth and progression. Because scientists often call these molecules “molecular targets,” targeted cancer therapies are sometimes called “molecularly targeted drugs. Advances in molecular biology, cellular biology and genomics have substantially increased the detailed understanding of the molecular pathology of cancer in terms of genetic mutation, altered gene expression and the…

    • 1137 Words
    • 5 Pages
    Better Essays
  • Powerful Essays

    ImClone Crisis Management

    • 2376 Words
    • 10 Pages

    ImClone Systems is a New York City based firm specializing in research and development of treatments and cures of cancer. The company’s Erbitux (C-255) product was not FDA approved as of the date of this occurrence, though it has been released for “compassionate Use” program under the FDA regulations. This enables the company to provide treatment to patients with terminally ill circumstances, who have not been included in the various clinical trials which are conducted by the company.…

    • 2376 Words
    • 10 Pages
    Powerful Essays
  • Good Essays

    J. Jamel, (2009). Cancer Treatment Centers of America- It 's You v. Your Doctor. Retrieved September 19, 2012 from http://thiscommercialsucks.blogspot.com/2009/04/cancer-centers-of-america-its-you-v.html.…

    • 1060 Words
    • 5 Pages
    Good Essays
  • Satisfactory Essays

    Non-Small Cell Lung Cancer (NSCLC) is the most common lung cancer, and the second-most common cancer in men and women. Historically, the treatment paradigm has centered around chemotherapy. However, the launch of targeted therapies for patients with specific biomarkers has begun to fragment the NSCLC treatment landscape into smaller niche patient populations. Over the forecast period, this trend will continue with the launch of multiple new drugs in several new drug classes to address the high unmet need among NSCLC patients, and provide new treatment options for previously underserved populations. Launch of premium-priced drug candidates combined with increasing incident cases of the disease will be major drivers of growth in the major markets.…

    • 657 Words
    • 4 Pages
    Satisfactory Essays
  • Good Essays

    Cancer Cure Speech

    • 616 Words
    • 2 Pages

    This cure was discovered a long while ago and has been proven to kill every single type of cancer. You may be sat there thinking “what on earth is she on about? One simple drug, isn’t going to cure all the different kind of cancers in the world? There are hundreds of them!” Well you’re right about there being hundreds of them, but they’re not all that different. They all start in the same way.…

    • 616 Words
    • 2 Pages
    Good Essays

Related Topics