Propofol Infusion Case Study

Topics: Surgery, Medicine, Physician, Patient, Anesthesia, Hospital / Pages: 16 (3793 words) / Published: Mar 31st, 2017

Comparison of Propofol infusion with Sevoflurane mask

for Sedation of Children Undergoing Magnetic Resonance


Ashraf Abualhassan ,MD, Lecturer of Anesthesia, Faculty of Medicine,Menoufiya University.

Monaz Abdulrahman,MD, Lecturer of Anesthesia, Faculty of Medicine,Menoufiya Universty.

Touma Chamieh,FACHARZT Degree ,Anesthesia consultant.

Background: The number of diagnostic procedures done outside the operating room for children has

increased dramatically in the recent years. These procedures require sedation, analgesia or both to

achieve co-operation and immobilization to complete the procedure successfully.

Objectives: The aim of this study was to compare propofol infusion and sevoflurane inhalation
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(2)Duration of procedure (Duration of sedation): Time in minutes from the start of the proce-

dure to the termination of the procedure.

(3) Recovery time: Time in minutes between discontinuation of the study drug to spontaneous

eye opening (Ramsay score 2).

(4) Time to discharge: The time in minutes from discontinuation of the study drugs till the

discharge of the child from the PACU (modified Aldrete score of ≥ 8).

(5) Additional sedation: Administration of further doses of the primary sedative drug to

achieve deep sedation

(6) Failed sedation: inadequate sedation after maximum dose of the primary drug leading to

inability to complete the procedure.

(7) Respiratory problems: wheezing, laryngeal spasm, apnea or desaturation that requires

interference to ensure patient safety and airway patency.

(8) Cardiovascular problems: significant bradycardia, hypotension or arrhythmia.

(9) GIT problems: nausea, vomiting, and hiccups.

(10) Agitation score: immediately after transfer to the PACU. (1 = Sleep,2 = Calm,3 = Crying

but consoled, 4 = Crying and cannot be consoled, 5 = Agitated and thrashing around (8)
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Table (2): Times in minutes for sedation, recovery and discharge in both groups.

* P value is significant if < 0.05.

Before sedation there were no statistically significant differences between both groups as

regards HR, MAP and RR.

In group P, HR decreased significantly during all times of measurements after starting

sedation when compared to the baseline value (P value < 0.01) on the other hand in group S,

HR did not change significantly from the baseline (p value ˃ 0.05). On comparing both

groups, HR was significantly lower in group P than group S at all times after the base line.

(P value ˂ 0.05) (Figure 1).

*Figure (1) Heart rate changes in beat / min in both groups *Intergroup difference.



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