Propofol Infusion Case Study
Comparison of Propofol infusion with Sevoflurane mask
for Sedation of Children Undergoing Magnetic Resonance
Ashraf Abualhassan ,MD, Lecturer of Anesthesia, Faculty of Medicine,Menoufiya University.
Monaz Abdulrahman,MD, Lecturer of Anesthesia, Faculty of Medicine,Menoufiya Universty.
Touma Chamieh,FACHARZT Degree ,Anesthesia consultant.
Background: The number of diagnostic procedures done outside the operating room for children has
increased dramatically in the recent years. These procedures require sedation, analgesia or both to
achieve co-operation and immobilization to complete the procedure successfully.
Objectives: The aim of this study was to compare propofol infusion and sevoflurane inhalation …show more content…
(2)Duration of procedure (Duration of sedation): Time in minutes from the start of the proce-
dure to the termination of the procedure.
(3) Recovery time: Time in minutes between discontinuation of the study drug to spontaneous
eye opening (Ramsay score 2).
(4) Time to discharge: The time in minutes from discontinuation of the study drugs till the
discharge of the child from the PACU (modified Aldrete score of ≥ 8).
(5) Additional sedation: Administration of further doses of the primary sedative drug to
achieve deep sedation
(6) Failed sedation: inadequate sedation after maximum dose of the primary drug leading to
inability to complete the procedure.
(7) Respiratory problems: wheezing, laryngeal spasm, apnea or desaturation that requires
interference to ensure patient safety and airway patency.
(8) Cardiovascular problems: significant bradycardia, hypotension or arrhythmia.
(9) GIT problems: nausea, vomiting, and hiccups.
(10) Agitation score: immediately after transfer to the PACU. (1 = Sleep,2 = Calm,3 = Crying
but consoled, 4 = Crying and cannot be consoled, 5 = Agitated and thrashing around (8) …show more content…
Table (2): Times in minutes for sedation, recovery and discharge in both groups.
* P value is significant if < 0.05.
Before sedation there were no statistically significant differences between both groups as
regards HR, MAP and RR.
In group P, HR decreased significantly during all times of measurements after starting
sedation when compared to the baseline value (P value < 0.01) on the other hand in group S,
HR did not change significantly from the baseline (p value ˃ 0.05). On comparing both
groups, HR was significantly lower in group P than group S at all times after the base line.
(P value ˂ 0.05) (Figure 1).
*Figure (1) Heart rate changes in beat / min in both groups *Intergroup difference.
0 5 10 15 20 25 30 35 40 45 50 55