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Progeria
Hutchinson-Gilford Progeria Syndrome

Abstract
Hutchinson - Gilford syndrome, or Progeria, is an extremely rare genetic disorder when children age at a tremendous pace. Although children born with Porgeria tend to look healthy, they begin to display many characteristics of fast-tracked aging around 18-24 months. These children develop growth failure, a loss of body fat and hair, aged-looking skins, stiffness of joints, cardiovascular disease and strokes. Children with Progeria die of atherosclerosis (heart disease) at an average age of thirteen years (with a range of about 8 – 21 years). Progeria is extremely uncommon; only about one out of eight million people have it. Ninety percent of children with Progeria have a mutation on the gene that encodes the protein lamin A, and usually occurs (without cause). Progeria fell to my interest because these patients touch the heart of many human beings with their struggles of aging and death at a very young age. This paper will give you all the basic details of the genetic disorder, displaying and answering what Progeria is, the causes, journey and treatments. Many of the resources are from books, journals, and websites. Old at age 3 by Zachary Moore, and W. Ted Brown’s and Frank Rothman’s (title of book chapter is from) chapter entitled the “Hutchinson-Gilford Progeria Syndrome” are some helping book sources. Also I found journals on PubMed, and information from internet sources, such as the Progeria research foundation.

Outline
I. Intro
A. Intro thoughts
B. Definition
C. Thesis
II. Progeria
A. Definition
B. Origin
C. Inheritance
D. Life expectancy
E. Founders
III. Epidemiology
A. Progerian population
B. Location where found
C. Ethnicity
D. Appearance
IV. Symptoms
A. Physical Appearance
1. Growth failure
2. Loss of body fat and hair
3. Aged looking skin
4. Enlarged skull
B. Health Problems
1. Stiffness of joints,
2. Hip dislocation
3. Generalized atherosclerosis
4. Cardiovascular disease
5. Stroke
V. Causes
A.


Cited: "Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria." Developmental Cell 19.3 (2010): 413-25. Print. Hui Liu, Guang Gilford Progeria Syndrome." Nature: International Weekly Journal of Science 1st ser. 1.1 Hutchinson (2011). Print. Online, Credit Card "Human Progeroid Syndromes, Aging and Cancer: New Genetic and Epigenetic Insights into Old Questions." Cellular and Molecular Life Sciences 64.2 (2007): 155-70. Print.
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