Practice 4A 1

Introduction to Biochemistry
(CHEM 501)
Final Exam
12/17/2007
1. The anaerobic conversion of 1 mol of glucose to 2 mol of lactate by fermentation is accompanied by a net gain of:
a)
b)
c)
d)
e)

1 mol of ATP.
1 mol of NADH.
2 mol of ATP.
2 mol of NADH. none of the above.

2. The conversion of 1 mol of fructose 1,6-bisphosphate to 2 mol of pyruvate by the glycolytic pathway results in a net formation of:
a)
b)
c)
d)
e)

1 mol of NAD+ and 2 mol of ATP.
1 mol of NADH and 1 mol of ATP.
2 mol of NAD+ and 4 mol of ATP.
2 mol of NADH and 2 mol of ATP.
2 mol of NADH and 4 mol of ATP.

3. Which of the following statements is not true concerning glycolysis in anaerobic muscle?
a)
b)
c)
d)
e)

Fructose 1,6-bisphosphatase is one of the enzymes of the pathway.
It is an endergonic process.
It results in net synthesis of ATP.
It results in synthesis of NADH.
Its rate is slowed by a high [ATP]/[ADP] ratio.

4. When a muscle is stimulated to contract aerobically, less lactic acid is formed than when it contracts anaerobically because:
a)
b)
c)
d)

glycolysis does not occur to significant extent under aerobic conditions. muscle is metabolically less active under aerobic than anaerobic conditions. the lactic acid generated is rapidly incorporated into lipids under aerobic conditions. under aerobic conditions in muscle, the major energy-yielding pathway is the pentose phosphate pathway, which does not produce lactate.
e) under aerobic conditions most of the pyruvate generated as a result of glycolysis is oxidized by the citric acid cycle rather than reduced to lactate.

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5. Glycolysis in the erythrocyte produces pyruvate that is further metabolized to:
a)
b)
c)
d)
e)

CO2. ethanol. glucose. hemoglobin. lactate.

6. In glycolysis, fructose 1,6-bisphosphate is converted to two products with a standard freeenergy change (ΔG'°) of 23.8 kJ/mol. Under what conditions (encountered in a normal cell) will the free-energy change (ΔG’) be negative, enabling the reaction to proceed to the