Paget Disease Psychoanalysis

Paget Disease of the bone was first described by English surgeon Sir James Paget in 1876. He observed certain clinical findings in five male patients. Each of these individuals displayed certain deformities on a minimum of two skeletal areas. When describing this condition, he used the term osteitis deformans by which the disease is also known. He felt, at first, that he was describing a rare inflammatory-type disorder. However, there were soon numerous papers published on similar findings in patients from England as well as the United States and France. By 1901, osteolytic disease could be recognized following the discovery of the x-ray in 1895(1-33citation). Since that time, much more has been discovered about the disease. More distinct signs and symptoms have been observed as well as etiological factors and treatment options. Paget Disease can have an impact on many areas of the human skeletal
There are, however, a number of theories that have been suggested. One of the proposed theories is that the disease is caused by a slow viral infection. Upon studying osteoclasts of individuals with Paget Disease, it was found that the cells contained components that were mainly identical and related to the viral family, paramyxoviridae. A number of studies have supported this idea, although, not all had the positive confirmation of the virus present in the cells. Genetic factors have also been studied for links to the disease. In approximately forty percent of individuals with Paget Disease, it has been found that a family member or family members have also had the disease. Several genes on various chromosomes, such as chromosomes five and eighteen, have been studied for the linkage of the disease. Though some individual cases have had a positive link, others have not(citation1-33). This leaves the theory unresolved. Research, hopefully, will continue to find the underlying cause of this