Over-Counter Painkilling Drugs Essay
Title: Separation and Identification of the major components of common over-the-counter painkilling drugs
Purpose: 1.To separate acetaminophen, aspirin and caffeine from painkilling drugs. 2.To determine the melting points of acetaminophen, aspirin and caffeine 3.To identify the separated components(acetaminophen, aspirin and caffeine) by thin-layer chromatography
Apparatus and Reagents Used :
1. 4:1 (v/v) 1-Butyl ethanoate/ethanoic acid
2. 3M Sodium hydroxide solution
3. 3M Hydrochloric acid
4. Iodine
5. Dichloromethane
6. Ethanol
7. Anhydrous MgSO4
8. Mortar and pestle
9. Beakers
10. Capillary tubes(Melting-point tubes)
11. TLC plates
12. Painkilling tablets
13. pH papers
14. Test tubes
15. Conical flasks
16. TLC …show more content…
The aspirin in the form of a water-soluble salt can be separated by simple filtration due to the immiscibility between water and dichloromethane. For the identification of those products obtained, melting-point determination and thin-layer chromatography is carried out. Thin-layer chromatography could act as a useful means of quickly characterizing the main active ingredients of aspirin, caffeine and acetaminophen when they do not have many other organic compounds in significant proportions. Compared with different Rf values of each other, the interrelationship among them could be found. That is a test checking whether there are any same components among the 3 commercial analgesics.
Procedures:
A. Separation of acetaminophen/binder from aspirin/caffeine
1.The given tablets were grinded to very fine powder in a mortar.
2.This powder was placed in a conical flask with adding 10cm3 of dichloromethane.
3.The conical flask was put into a beaker of warm water at 30 oC.
4.The solution was filtrated.
B. Separation of aspirin and
Purpose: 1.To separate acetaminophen, aspirin and caffeine from painkilling drugs. 2.To determine the melting points of acetaminophen, aspirin and caffeine 3.To identify the separated components(acetaminophen, aspirin and caffeine) by thin-layer chromatography
Apparatus and Reagents Used :
1. 4:1 (v/v) 1-Butyl ethanoate/ethanoic acid
2. 3M Sodium hydroxide solution
3. 3M Hydrochloric acid
4. Iodine
5. Dichloromethane
6. Ethanol
7. Anhydrous MgSO4
8. Mortar and pestle
9. Beakers
10. Capillary tubes(Melting-point tubes)
11. TLC plates
12. Painkilling tablets
13. pH papers
14. Test tubes
15. Conical flasks
16. TLC …show more content…
The aspirin in the form of a water-soluble salt can be separated by simple filtration due to the immiscibility between water and dichloromethane. For the identification of those products obtained, melting-point determination and thin-layer chromatography is carried out. Thin-layer chromatography could act as a useful means of quickly characterizing the main active ingredients of aspirin, caffeine and acetaminophen when they do not have many other organic compounds in significant proportions. Compared with different Rf values of each other, the interrelationship among them could be found. That is a test checking whether there are any same components among the 3 commercial analgesics.
Procedures:
A. Separation of acetaminophen/binder from aspirin/caffeine
1.The given tablets were grinded to very fine powder in a mortar.
2.This powder was placed in a conical flask with adding 10cm3 of dichloromethane.
3.The conical flask was put into a beaker of warm water at 30 oC.
4.The solution was filtrated.
B. Separation of aspirin and