Oligomycin: The Killer Antibody

Pages: 4 (1176 words) Published: October 12, 2008
Oligomycin: The Killer Antibody
Discovered in 1953, this antibiotic produced by gram positive streptomyce bacterial family, causes death in human by prematurely stopping the process of oxidative phosphorylation inside the mitochondrion. By forming irreversible non-covalent, polar and Schiff base bonds with the N terminal and the C terminal of the polypeptide chain, changing the active sites, proton bearing sites, and therefore stopping the movement of the protons through the ingredient. Structure and Properties:

Oligomycin complex is composed of 2 sets of isomers along with a diastemor for one of the isomers.  
Oligomycin A Oligomycin B The two are active isomers differing in the # of oxygen and hydrogen present Oligomycin A with formula C45H74O11 contains 2 extra hydrogens on the carbon of the deoxy sugar attached to the macrocyclic ring. In contrast the oligomycine B contains extra oxygen at the same carbon site instead of the two hydrogens; increasing the number of oxygen by 1 and decreasing the hydrogen by 2. Such change has resulted in slight difference in the molecular weight of the two compounds. CompoundformulaMolecular weight

Oligomycin AC45H74O11 791.06 g/mol
Oligomycin BC45H72O12841.08 g/mol

To understand the function of a molecule one must analyze the structure of a compound.

Oligomycin is categorized as a macrolide molecule. Macrolid refers to group of antibiotic and drugs produced in nature by living organisms 
Macrocyclic lacton rings refer to the large cyclic rings composed of the minimum of 14-15-16 carbons ad maximum of 30. As indicated in the diagram the lacton rings are always connected to 1 or 2 deoxy sugars. Lactones...
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