Obesity And Homeostasis

The interaction between obesity and the skeletal system is complex. Typically, obesity is thought to promote bone formation and prevent the occurrence of bone loss and osteoporosis. The bone is a dynamic organ which exists in homeostasis by the balance of two opposing processes, bone resorption and bone remodeling. Bone resorption is mediated by osteoclasts (OC) while bone matrix synthesis is primarily formed by the action of osteoblasts (OB). An imbalance of OB or OC function leads to abnormalities of the bone[1,2] .
Recent studies have shown that obesity and the risk of bone fractures are closely associated[3].Contrary to the traditional paradigm,there is increasing recognition that excess abdominal adipose tissue can be a risk factor for