narcotics

Topics: Morphine, Cocaine, Drug addiction, Heroin, Opium / Pages: 5 (1135 words) / Published: Feb 7th, 2014
CM8002 Drugs

Saferstein Chapter 8

Drugs
Natural
Used since ancient times, mostly by “medicine men”
Semi-synthetic
Modified natural compounds
Synthetic
Misuse of pharmaceutical results
Abuse of solvents

Physical and Psychological addiction www.cnb.gov.sg www.dea.gov

Drugs
“The fly agarics are dried and eaten in large pieces. After about half an hour, the person becomes completely intoxicated and experiences extraordinary visions.
CO2H
O
Those who cannot afford the high
N
NH2 price of the mushrooms drink the urine of those who have eaten,
HO
whereupon they become
Ibotenic acid - interferes intoxicated, if not more so” with neurotransmitters in the brain

Georg Steller in Siberia, 1774

Peyote and Mescaline
Used in Mexican religions for 1000s of years; spread to Native
Americans in the S.W. in late C19th.

Lophophora williamsii

Illegal in the USA except for religious purposes
H3C
H3C

O

NH2

O
O

CH3

mescaline

Cannabis, hemp, hashish
Widely known in China,
Central Asia, India,
Middle East since
2000BC; fibres used for rope making since Roman times Described by Marco Polo; habit brought to Europe first by Napoleon’s soldiers
Saferstein page 209-211

Cannabis, marijuana, pot, grass
Herbal material from

cannabis sativa

Usually smoked
Identified botanically
- shape of leaves
- smell
- cystolithic trichomes
- may be confused with hops
Cannabis resin and cannabis oil

Cannabis chocolate

www.usdoj.gov/dea/multimedia.html

and vodka

Cannabis
H
H
O

OH

8-tetrahydrocannabinol

multiple effects on the CNS
Reported to be effective against side effects of chemotherapy
(synthetic alternatives now available) - medical sales legal in 14
US states

(http://news.bbc.co.uk/2/hi/americas/8319950.stm)

Detect active ingredient in samples by HPLC
Plant samples can be compared by DNA

Cannabis: smuggled or grown

Gifts from the New World to the Old

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