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Myrica Capassa Lab Report

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Myrica Capassa Lab Report
ABSTRACT
Purpose: To evaluate the antifungal and cytotoxicity activity of four medicinal plants like Mystroxylon aethiopicum, Lonchocarpus capassa, Albizia anthelmentica and Myrica salicifolia.
Methods: Microdilution method and brine shrimp lethality test were employed to evaluate antifungal and cytotoxicity of plant extracts.
Results: Lonchocarpus capassa leaf extracts exhibited antifungal activity against tested fungal strains with MIC range of 0.78 – 3.125 mg/mL with LCLA extract inhibiting C. albicans and C. neoformans at MIC value of 0.781 mg/mL. LCLE extract inhibited C. albicans and C. neoformans with MIC values of 3.125 and 0.781 mg/mL respectively. Myrica salicifolia and Albizia anthelmentica extracts exhibited antifungal activity with MIC range of 3.125 – 12.5 mg/mL whilst Mystroxylon aethiopicum extracts had MIC range of 6.25 – 12.5 mg/mL. Cytotoxicity assay revealed that LCLA extract which displayed good antifungal activity was cytotoxic against brine shrimp larvae with LC50 value of 17.861 µg/mL. It was shown that 33% of plant extracts exhibited high cytotoxicity with LC50 values below that of standard anticancer …show more content…
salicifolia revealed that, leaf extracts selectively inhibited the growth of C. neoformans with MIC value of 3.125 mg/mL. This suggests that the leaves of this plant provide evidence of the efficacy of secondary metabolites to treat fungal infections caused by this pathogen. According to Godfrey et al [26], utilization of leaves is highly recommended for sustainability of plants as the use of roots and stems increases risk of plants extinction. These results are in agreement with the traditional use of M. salicifolia leaves by Pare people in the Northern Tanzania for treatment of skin diseases [27]. Regarding M. aethiopicum, none of the extract exhibited antifungal activity with MIC value below 3.125 mg/mL and therefore suggest that the plant does not contain active ingredients against selected fungal
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