MS481 Term Project Literature Review1
MS481 Term Project Literature Review
Path Calculation for Heterogenerous Porous Scaffold Design
14060 Ezgi Küçükdeğer
15371 Büşra Selin Demir
Supervised by Bahattin Koç
November 17, 2014
Sabanci University
Faculty of Engineering and Natural Sciences
Manufacturing Systems and Industrial Engineering
Fabrication of medical parts can be done by using additive manufacturing technology. One approach which is more suitable for regeneration of tissue structure is to form a scaffold which is made of a biocompatible material so that vascularization and cell ingress will be enabled. This scaffold will represent the shape of the final tissue construction and later living cells will be added. The scaffold geometry should include porous structure where pores are large enough in diameter to allow cell ingrowth but also should be balanced and not causing decrease in strength. The mechanical properties of the porous scaffold are highly crucial in that sense. In this literature review we will examine different approaches from different scientists.
Tissue Engineering
Scaffold geometry should represent the native tissue properly. For better representation, the scaffold geometry should include porous structure where pores are a few hundred microns across and this size allows cell ingrowth. If the scaffold has a micro-porosity, the cells can insert fibrils so that they can attach firmly to the scaffold walls. Most of the approaches use bioreactors to enhance reproduction of the cells. For example, a mixture of polcaprolactone (PCL) which is biodegradable and acts as a matrix materialis used to manufacture a scaffold for producing a mixture of bone and cartilage and then implanted into a rabbit in one of the studies. Also, adding tri-calcium phosphate (TCP) improves the biocompatibility to enhance bone regeneration. But still it is difficult to maintain the integrity of the scaffold for a long time enough to form healthy and strong bone(Gibson, Rosen, & Stucker, 2010, p.
Path Calculation for Heterogenerous Porous Scaffold Design
14060 Ezgi Küçükdeğer
15371 Büşra Selin Demir
Supervised by Bahattin Koç
November 17, 2014
Sabanci University
Faculty of Engineering and Natural Sciences
Manufacturing Systems and Industrial Engineering
Fabrication of medical parts can be done by using additive manufacturing technology. One approach which is more suitable for regeneration of tissue structure is to form a scaffold which is made of a biocompatible material so that vascularization and cell ingress will be enabled. This scaffold will represent the shape of the final tissue construction and later living cells will be added. The scaffold geometry should include porous structure where pores are large enough in diameter to allow cell ingrowth but also should be balanced and not causing decrease in strength. The mechanical properties of the porous scaffold are highly crucial in that sense. In this literature review we will examine different approaches from different scientists.
Tissue Engineering
Scaffold geometry should represent the native tissue properly. For better representation, the scaffold geometry should include porous structure where pores are a few hundred microns across and this size allows cell ingrowth. If the scaffold has a micro-porosity, the cells can insert fibrils so that they can attach firmly to the scaffold walls. Most of the approaches use bioreactors to enhance reproduction of the cells. For example, a mixture of polcaprolactone (PCL) which is biodegradable and acts as a matrix materialis used to manufacture a scaffold for producing a mixture of bone and cartilage and then implanted into a rabbit in one of the studies. Also, adding tri-calcium phosphate (TCP) improves the biocompatibility to enhance bone regeneration. But still it is difficult to maintain the integrity of the scaffold for a long time enough to form healthy and strong bone(Gibson, Rosen, & Stucker, 2010, p.
References: Bonfield, W. (2005, November 29). Designing porous scaffolds for tissue engineering. Philosophical Transactions of the Royal Society , s. 227-232. Drury, J. L., & Mooney, D. J. (2003). Hydrogels for tissue engineering: scaffold desing variables and applications. Biomaterials , s. 4337-4351. Gibson, I., Rosen, D. W., & Stucker, B. (2010). Additive Manufacturing Technologies. New York: Springer Science+Business Media. Khoda, B., & Koc, B. (2013, May 19). Functionally heterogeneous porous scaffold design for tissue engineering. Computer-Aided Design, pp. 1276-1293.