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Chemicals

SAMPLE NAME: Paracetamol Tablets
ANALYSIS REQUIRED: Paracetamol
CLAIM: Each tablet contains 500mg Paracetamol.
THEORY:
Paracetamol
IUPAC Name: N-(4-hydroxyphenyl)ethanamide N-(4-hydroxyphenyl)acetamide
Molecular Formula: C8H9NO2
Chemical Structure:
Paracetamol INN or acetaminophen USAN is a widely used over-the-counter analgesic (pain reliever) and antipyretic (fever reducer). It is commonly used for the relief of headaches and other minor aches and pains and is a major ingredient in numerous cold and flu remedies. In combination with opioid analgesics, paracetamol can also be used in the management of more severe pain such as post-surgical pain and providing palliative care in advanced cancer patients. The onset of analgesia is approximately 11 minutes after oral administration of paracetamol, and its half-life is 1–4 hours. Though acetaminophen is used to treat inflammatory pain, it is not generally classified as an NSAID because it exhibits only weak anti-inflammatory activity.
PROCEDURE:
* Weighed 10 tablets and calculated the average weight of 1 tablet. * Calculated the sample to be taken according to the claim. * Crushed the tablets in a pestle and mortar.
Preparation of the Test Dilution: * Weighed around 86 mg of the sample. * Transferred the sample in a 100 ml volumetric flask. * Made up the volume to 100ml with 0.1N NaOH. * Transferred 2 ml of the above solution in a 100 ml volumetric flask. * Made up the volume to 100 ml with 0.1N NaOH. * Filtered the above solution in a test tube.
Preparation of the Standard Dilution: * Weighed about 51 mg of the standard. * Transferred it in a 100 ml volumetric flask. * Made up the volume to 100 ml with 0.1N NaOH. * Transferred 2 ml of the above solution in a 100 ml volumetric flask. * Made up the volume to 100 ml with 0.1N NaOH. * Filtered the above solution in a test tube.
For the measurement of the OD: * Started the Spectal Manager Software, Clicked on

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