Metabolic Superstorm

Topics: Muscle, Skeletal muscle, Myosin, Acetylcholine, Muscle contraction, Muscular system / Pages: 4 (869 words) / Published: Nov 30th, 2014
Metabolic Superstorm

1. Fill in the chart below. Use “+” if the patient’s vital sign is higher than normal, “−” if the sign is lower than normal, or “x” if the sign is normal. If you need to, use your text or another resource to determine normal values.

Vital Sign Increase/Decrease/Normal

Respiration Rate +
Heart Rate +
Blood Pressure -
Body Temperature +

2. If you were the doctors on the scene, what diagnosis would you give this patient? (You may use the internet to help diagnose the patient.)

I would question as to whether he has any allergies. The heart rate and respiration elevation, and low blood pressure can be present in allergic reactions.

3. Jot down some notes about your diagnosis, and bring these to class with you for discussion.

Does the patient have allergies? Is he taking any medication (obviously the anesthesia).

Assignment 2

3. In the above article, what is the “veritable metabolic storm” that the author refers to? What molecular changes are reported in pig muscles during a MH state?

The “veritable metabolic storm” refers to rapid heart rates and breathing, abnormal muscle stiffening, blotchy blueness of the skin, and a rapid rise in temperature. The pig muscles lose adenosine triphosphate and release a tremendous amount of acid and potassium, which helps to stop their hearts. 4) Arrange muscle contraction cards:
1. Neuron action potential arrives at end of motor neuron
2. ACH is released
3. ACh binds to receptors on motor end plate
4. Permeability of sarcolemma changes (Na rushes in)(an action potential is produced)
5. Muscle action potential sweeps into the T tubules triggering
6. release of Ca from the cisternae of the sarcoplasmic reticulum
7. CA binds to troponin
8. Troponin changes shape and shifts tropomyosin to expose binding sites of actin
9. myosin binds to actin (cross bridge is formend)(ADP released from myosin)
10. Myosin head pivots (pulling actin)

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