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Mechanism of Action

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Mechanism of Action
1. Ceftriaxone Sodium 1g IV

Fig. 1.1 Ceftriaxone (Rocephin)
It inhibits the cell wall synthesis promoting osmotic instability, usually bactericidal. It hinders or kills bacteria.
Ceftriaxone sodium is a broad-spectrum bactericidal cephalosporin antibiotic. Ceftriaxone is active in vitro against a wide range of Gram-positive and Gram-negative organisms, which include β-lactamase producing strains.
Ceftriaxone is indicated in the treatment of the following infections either before the infecting organism has been identified or when known to be caused by bacteria of established sensitivity.

Fig. 1.2 Chemical Formula of Ceftriaxone

2. Metronidazole 5mg/100 ml IV

Fig. 2.1 Metronidazole (Dazomet) Powder for Injection
Metronidazole is an antimicrobial drug with high activity against anaerobic bacteria and protozoa.
Direct-acting trichomonacide and amebicide that works at both intestinal and extraintestinal sites.
Metronidazole hinders the growth of selected organisms, including most anaerobic bacteria and protozoa.

Fig. 2.2 Chemical Formula of Metronidazole

3. Cefuroxime 750 mg IV

Fig. 3.1 Cefuroxime (Cethixim) 750 mg
Cefuroxime is indicated in the parenteral treatment of the following infections caused by cefuroxime sensitive pathogens.
All cephalosporins (β-lactam antibiotics) inhibit cell wall production and are selective inhibitors of peptidoglycan synthesis. The initial step in drug action consists of binding of the drug to cell receptors, called Penicillin-Binding Proteins. After a β-lactam antibiotic has bound to these receptors, the transpeptidation reaction is inhibited and peptidoglycan synthesis is blocked. Bacterial lysis is the end result.
It inhibits the cell wall synthesis promoting osmotic instability; usually bactericidal. It hinders or kills susceptible bacteria, including many gram positive organisms and enteric gram-negative bacilli.

Fig. 3.2 Chemical Formula of Cefuroxime 1. Omeprazole

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