Marfan Syndrome Background

The history and background of marfan disease. Marfan syndrome (MFS) is an inherited connective tissue disorder noteworthy for its worldwide distribution, relatively high prevalence, and clinical variability. This autosomal dominant syndrome has pleiotropic manifestations involving primarily the ocular, cardiovascular, and skeletal systems. Classic marfan syndrome MFS type 1, MFS1 has been considered a condition caused by the deficiency of a structural extracellular matrix protein, fibrillin-1; however, studies of Marfan mouse models and Marfan-related conditions have expanded our current understanding to a pathogenic model that involves dysregulation of cytokine-transforming growth factor beta TGFβ signaling. [1, 2] . Patients who have clinical
In the past, people who had Marfan syndrome rarely lived past 40. With regular monitoring and modern treatment, most people with Marfan syndrome can now expect to live a more normal life span. Some problems with marfan's disease is that you're not expected to live a long and happy life. And have heart disease and swelling inside the stomach which causes death. The swelling in the stomach can eventually rupture and can seriously injure your body. Often time people have severe pain in the chest, stomach, and back.When this happens you should immediately receive medical attention. Some interesting facts about marfan's syndrome. Most people don't know this but, abraham lincoln had marfan's. Marfan's syndrome was first described in 1896 by a french pediatrician. Also people with marfan syndrome that need to get teeth pulled is very dangerous because pulling a tooth from someone that has marfan's syndrome could kill them. People with Marfan syndrome shouldn't do lots of running, physical contacts, or getting hit in the chest. Also sports like baseball, basketball, football, track. People with this disease are stuck with for the rest of their