Lung Cancer Research

“Lung cancer continues to be the leading cause of death in both men and women in the US, with over 158,900 deaths in 1999. Worldwide, lung cancer kills over 1 million people a year. Extensive prospective epidemiologic data clearly establish cigarette smoking as the major cause of lung cancer. It is estimated that about 90% of male lung cancer deaths and 75–80% of lung cancer deaths in the US are caused by smoking each year” (Hecht, 1999). Clearly, lung cancer is an important and widespread disease that constitutes a major public health problem. This was not always so. Some 150 years ago, it was an extremely rare disease. In 1878, malignant lung tumors represented only 1% of all cancers seen at autopsy in the Institute of Pathology of the University of Dresden in Germany. By 1918, the percentage had risen to almost 10% and by 1927 to more than 14%. In the 1930 edition of the authoritative Springer Handbook of Special Pathology it was duly noted that malignant lung tumors had begun to increase at the turn of the century and perhaps even more so after World War I and that, possibly, they still were on the increase. It was also noted that while most lung tumors occurred in men, there seemed to be a steady increase in women. Duration of the disease, from being recognized until death, was usually from half a year to 2 years and in practically all cases there had been a long history of chronic bronchitis.

What caused such a dramatic increase in an obscure disease? The handbook discusses at some length possible etiologic factors: increased air pollution by gases and dusts, caused by industry; the asphalting of roads; the increase in automobile traffic; exposure to gas in World War I; the influenza pandemic of 1918; and working with benzene or gasoline. However, lung cancer rose at the same rate in countries with fewer automobiles, less industry, fewer paved roads, and in workers not exposed to benzene or gasoline—and had not risen in the 19th century after earlier flu