Lou Gehrig's Disease

Amyotrophic lateral sclerosis known by an another name as Lou Gehrig’s disease affects atleast 2,000 individuals a year in England from onset between 50 years and 70 years. Amyotrophic comes from the Greek language. Damage Signs of lower motor neuron and upper motor neuron is not explained by any other disease process, and are the reasons behind ALS. It attacks nerve cells called neurons in the CNS. They transmit messages from central nervous system to the voluntary muscles - the ones we can control, like limbs . At initial stage , this causes mild muscle problems. Some patients show symptoms like-trouble walking, trouble in writing, speech problems. Gradually the strength is lost and the patient is unable to move. When muscles in the chest
These disorders are also associated with atrophy of the affected central or peripheral nervous system. The framework of health information on neurodegenerative diseases may also include brain diseases, which are pathologic conditions which affect the brain. The intracranial components include thalamus; basal ganglia, intracranial white matter, hypothalamus, brain stem, and cerebellum are included. Degenerative nerve diseases which include Alzheimer's disease, Parkinson's disease, Friedreich's ataxia, Spinal muscular atrophy, Lewy body disease, Huntington's disease. These all disorders are related with atrophy of the affected areas of central or peripheral nervous system. It is the basic term used for the gradual loss of normal functioning of neurons, including results in death of neurons. These diseases are incurable, which leads to neurodegeneration or death of neuron cells. Degenerative nerve diseases decreases many of the body's activities, such as movement, breathing, and heart function, balance, talking. These diseases are usually genetic. Some of the medical condition such as alcoholism, a tumor, or a stroke also contributes. Other causes may include certain toxins, viruses and chemicals. Sometimes the cause may not be identified. Treatments may be given to improve signs, relieve pain, and also to increase mobility .Unbiased. Novel associations to neurodegenerative diseases identified by unbiased genome-wide association studies (GWAS). Recently, GWAS of complex diseases and traits have been focused less on variants and more over the biological pathways and networks which are revealed by genetic associations. Pathologically, the characteristic of these diseases included are accumulation and aggregation of abnormal proteins, as with amyloid-β (Aβ) in ALS, α-synuclein in Parkinson’s disease (PD), huntingtin