Lornoxicam Essay

Clinically, non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently prescribed class of drugs for inflammatory disorders (1). Lornoxicam is a novel NSAID drug. It has an equipotent COX isoenzyme inhibitory effect and subsequently reduces the production of prostaglandins, thromboxane, and leukotrienes (2). It is prescribed for mild to moderate pain and inflammation in osteoarthritis and rheumatoid arthritis (3). It is prescribed for the treatment of osteoarthritis due to its analgesic, anti-inflammatory effect and to promote the repair of damaged joints (4).
It is classified as Class II drug with low solubility and high permeability properties. Due to its very poor solubility in acidic pH of the stomach, it remains in the stomach wall for a long period, aggravating its potential side effects (peptic ulcers and gastric irritation) (5).
Immediate release (IR) oral dosage forms, i.e., tablets and capsules, are designed to disintegrate in the stomach followed by their dissolution in the fluids of the gastrointestinal
Tablets containing liquid dissolution modulators (Liquitablets) are often prepared using direct compression technique with the aid of suitable carrier and coating materials. In our work, according to our knowledge, it is the first time to prepare liquitablets using blister molding method. Blister molding technique is a simple, easily scalable and requires no special equipment compared to the conventional