In early experimental models of the spike-and-wave activity which gave rise to the centrencephalic theory of epilepsy which suggested that the thalamus is the likely central driver of of epileptiform activity. The thalamo-cortical network is the major network that generates seizures. The thalamus displays rhythmic firing and has reciprocal connections to the cortex it has excitatory neurons arising from the dorsal thalamus that conveys information to cortical and thalamic projections to the reticular nucleus of the thalamus. The role of thalamo cortical networks is to maintain the sleep-wake cycle, awareness, and cognition. Absence seizures occur during wakefulness or while drowsing off. The fMRI studies of different patients with absence seizures have been used successfully in order to understand the structural and functional mechanisms of seizure generation. EEG along with fMRI allows us to recognized BOLD (blood oxygen level dependant) changes that are associated with absence
In early experimental models of the spike-and-wave activity which gave rise to the centrencephalic theory of epilepsy which suggested that the thalamus is the likely central driver of of epileptiform activity. The thalamo-cortical network is the major network that generates seizures. The thalamus displays rhythmic firing and has reciprocal connections to the cortex it has excitatory neurons arising from the dorsal thalamus that conveys information to cortical and thalamic projections to the reticular nucleus of the thalamus. The role of thalamo cortical networks is to maintain the sleep-wake cycle, awareness, and cognition. Absence seizures occur during wakefulness or while drowsing off. The fMRI studies of different patients with absence seizures have been used successfully in order to understand the structural and functional mechanisms of seizure generation. EEG along with fMRI allows us to recognized BOLD (blood oxygen level dependant) changes that are associated with absence