Preview

Leukemia: Bone Marrow and Treatment

Good Essays
Open Document
Open Document
4024 Words
Grammar
Grammar
Plagiarism
Plagiarism
Writing
Writing
Score
Score
Leukemia: Bone Marrow and Treatment
Leukemia

Leukemia or leukaemia (Greek leukos λευκός, "white"; aima αίμα, "blood") is a cancer of the blood or bone marrow and is characterized by an abnormal proliferation (production by multiplication) of blood cells, usually white blood cells (leukocytes). It is part of the broad group of diseases called hematological neoplasms.
Contents

* 1 Symptoms * 2 Four major types * 3 Causes and risk factors * 4 Treatment options for leukemia by type o 4.1 Acute Myelogenous Leukemia (AML) + 4.1.1 Initial treatment of AML + 4.1.2 Follow-up treatment + 4.1.3 Consolidation or maintenance therapy o 4.2 Chronic Myelogenous Leukemia (CML) o 4.3 Acute Lymphocytic Leukemia (ALL) o 4.4 Chronic Lymphocytic Leukemia (CLL) + 4.4.1 Transformation of CLL to high-grade disease or aggressive non-Hodgkin's lymphoma + 4.4.2 Chemotherapy for CLL o 4.5 Hairy Cell Leukemia (HCL) * 5 Research * 6 Incidence * 7 External links

Symptoms

Damage to the bone marrow, by way of displacing the normal bone marrow cells with higher numbers of immature white blood cells, results in a lack of blood platelets, which are important in the blood clotting process. This means people with leukemia may become bruised, bleed excessively, or develop pinprick bleeds (petechiae).

White blood cells, which are involved in fighting pathogens, may be suppressed or dysfunctional. This could cause the patient's immune system to be unable to fight off a simple infection or to start attacking other body cells.

Finally, the red blood cell deficiency leads to anemia, which may cause dyspnea. All symptoms can be attributed to other diseases; for diagnosis, blood tests and a bone marrow examination are required.

Some other related symptoms:

* Fever, chills, night sweats and other flu-like symptoms * Weakness and fatigue

You May Also Find These Documents Helpful

  • Powerful Essays

    Targeting unmet needs in the treatment of cancer/ hematological malignancies through innovative drug development strategies have witnessed favorable outcomes. Over the past decade, Proteasome inhibitor, Velcade (bortezomib) and the immunomodulatory drugs – Thalomid (thalidomide) and Revlimid (lenalidomide) have become the cornerstone of treatment for patients with Multiple Myeloma (MM) resulting in improved survival. However, eventually all patients relapse and new treatment options for Relapsed/ Refractory Multiple Myeloma (RRMM) are required to further improve survival and quality of life of this group of pts. Two new drugs have successfully fulfilled this need – POMALYST/ IMNOVID (pomalidomide – POM) and Kyprolis (carfilzomib-CFZ) but is there room for more?…

    • 712 Words
    • 3 Pages
    Powerful Essays
  • Satisfactory Essays

    All About Blood

    • 388 Words
    • 1 Page

    1. Lower than normal Hematocrit indicates Anemia. Hematocrit does not have enough Hemoglobin which is an oxygen carrying protein in red blood cells that results in having Iron, B12 and Folic Acid deficiencies. The main causes of developing Anemia include: medications and pregnancy, but the more serious causes include: kidney disease and cancer of the kidney, also leukemia and lymphoma.…

    • 388 Words
    • 1 Page
    Satisfactory Essays
  • Better Essays

    451 Nursing Practice Paper

    • 2950 Words
    • 12 Pages

    Leukemia is a neoplastic disease that involves the bloodforming tissues of the bone marrow, spleen, and lymph nodes. In…

    • 2950 Words
    • 12 Pages
    Better Essays
  • Satisfactory Essays

    Leukemia Case Summary

    • 276 Words
    • 2 Pages

    The beginning case that is first brought up by the parents of the deceased children who passed away to leukemia was blown off by Jan, “ I really wish I could help you but I can’t I’m sorry.” Jan is the man in charge of the small firm that later submitted a complaint against Beatrice Foods and W.R. Grace and Company. Shortly after returning back to the office Jan was given some information about what companies had factories out there, once he found out about how large the companies were he quickly returned to the parents and took the case. The whole reason backing the case was the fact that the rate of children getting leukemia was increasing dramatically, as well as everyone in town knowing about the water supply smelling disgusting and that factories there were a probably cause.…

    • 276 Words
    • 2 Pages
    Satisfactory Essays
  • Good Essays

    There are four types of HL, an uncommon form of lymphoma that involves the Reed-Sternberg cells. The four types are: Nodular sclerosing, Mixed cellularity, Lymphocyte rich and Lymphocyte depleted. There are more than 61 types of NHL, some of which are more common than others. Any lymphoma that does not involve Reed-Sternberg cells is classified as…

    • 624 Words
    • 3 Pages
    Good Essays
  • Better Essays

    Chronic myelogenous leukemia is a clonal bone marrow stem cell disease associated with a characteristic chromosomal translocation called the Philadelphia chromosome, named after the city where it was discovered.…

    • 1296 Words
    • 6 Pages
    Better Essays
  • Good Essays

    This yellow point consists of bacteria fighting white blood cells, which the body releases to counter…

    • 342 Words
    • 2 Pages
    Good Essays
  • Good Essays

    Rudolf Virchow from Germany was the first to use the term leukaemia in 1847. Ehrlich had introduced staining methods, the classification into acute lymphoid leukaemia became possible in 1913, and in 1973 ALL was divided into origin from B or T-lymphocytes.Acute lymphoblastic leukemia (ALL) is a malignant neoplasm of hematopoietic stem cells, highly occurring among children with a proportion of 30% of all pediatric malignancies. The initial peak incidence of this hematologic malignancy is at 2 to 5 years of age, followed by a second peak over age 50. Acute lymphoblastic leukemia (ALL) is a condition where genetic alterations in a single lymphoblast are inherited in all the cell’s descendants. The genetic alterations lead to accumulation of these leukemic clone cells with uncontrolled proliferation, which causes dysfunction of the bone marrow leading to mono- or pancytopenia and ultimately, if not treated, death.…

    • 365 Words
    • 2 Pages
    Good Essays
  • Good Essays

    The risks for the acute lymphoblastic leukemia are from radiation, genetic disorder, previous cancer treatment, or having a brother/sister with it. The treatments that people have more risk on getting ALL is on the radiation therapy and chemotherapy as for having another type of cancer may raise the risk even higher. This type of cancer usually affects children at 3-7 of age, but also occurs on adults. For treatment of the cancer the first one tried is the chemotherapy that is given in the veins or sometimes next to the spine and brain. The following therapies depend on the patient by their age and health, type of leukemia cells with the DNA changes, how many chemotherapies it took to achieve, and if there’s a stem cell transplant donor. Some choices that people have for the treatments are the consolidation therapy, destroys the remains in the brain and spinal cord; maintenance therapy, prevents the leukemia from growing; preventive therapy to spinal cord, kill leukemia cells in central nervous system during each phase. Also depending on how big or serious the person’s problem is the phase may take about 2 to 3…

    • 618 Words
    • 3 Pages
    Good Essays
  • Good Essays

    Acute Myeloid Leukemia

    • 752 Words
    • 4 Pages

    Leukemia is the tenth most prevalent cancer found in humans. The most common type of leukemia is acute myeloid leukemia. This type of leukemia begins in immature myeloid cells: white blood cells, red blood cells, or cells that make platelets known as megakaryocytes. Acute myelogenous leukemia is different from chronic myelogenous leukemia in that it spreads quicker and is much more deadly than the latter. Acute myeloid leukemia is characterized by the location of development, in stem cells, which are immature, also called “blasts.” Chronic leukemias form in the actual cell, after it has formed from a stem cell. AML does not divide more rapidly than normal cells, but it does not hit the checkpoint in which it is to stop dividing. It continues to divide.…

    • 752 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Leukemia Research Paper

    • 756 Words
    • 4 Pages

    Leukemia is cancer of the body's blood-forming tissues, as well as the bone marrow and lymphatic system and is thought to occur when some blood cells acquire mutations in their DNA. Many types of leukemia exist, some of which are more common in children and others more common in adults. Leukemia usually involves the white blood cells, which are strong infection fighters. The white blood cells normally grow and divide in an orderly way as your body needs them. But people with leukemia, the bone marrow produces abnormal white blood cells, which do not function properly. Certain abnormalities cause the cell to grow and divide more rapidly and to be able to continue living when normal cells would die. Over time, the abnormal cells crowd out…

    • 756 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Leukemia And Lymphoma

    • 183 Words
    • 1 Page

    Cancer occurs when cells in the human body start to divide out of control. Cells in nearly any part of the body can become cancerous and spread to other areas of the body. Leukemia and Lymphoma are two types of cancers. There are many differences between leukemia and lymphoma. First, leukemia is a disease which is characterized by an abnormal production of white blood cells. It is a cancer of the blood cells or bone marrow with numerous types and classifications. On the other hand, lymphoma is a tumor of the lymph nodes that causes lymph nodes to expand. In essence, the abnormal condition starts from the lymphatic system. Second, leukemia can affect people of any age group, although children. Lymphoma is more common in young people…

    • 183 Words
    • 1 Page
    Good Essays
  • Good Essays

    The goal of treatment is to reach a complete remission by obliterating all leukemia cells as quickly as possible. Remission is reached when any signs or symptoms of cancer disappear and abnormal cells are no longer found in the blood, bone marrow, or cerebrospinal fluid. The book Childhood Leukemia: A guide for Families, Friends & Caregivers says, “ The primary treatment for ALL is chemotherapy--the use of drugs especially designed to kill cancerous cells”(1). Treatment is usually broken up into 3 phases: remission induction, consolidation and intensification, and maintenance. Remission induction is the first phase with a goal of killing all leukemic cells sending the patient into remission. The second stage, consolidation and intensification, begins once the leukemia is in remission. The goal is to kill any cancer cells that may remain and may cause relapse. Maintenance, the final phase, kills any leukemia cells that may regrow or cause relapse. The goal of all 3 stages is to completely rid the body of leukemia…

    • 889 Words
    • 4 Pages
    Good Essays
  • Good Essays

    Leukemia

    • 358 Words
    • 2 Pages

    Chronic lymphocytic only occurs in adults does not occur in children, it mainly occurs in elderly males. This leukemia progresses very slowly and rarely needs to be treated. To diagnose chronic lymphocytic leukemia the blood, bone marrow, lymph nodes, ad spinal fluid would have to be tested. To classify the disease, the blood would be tested and compared. It can be treated by waiting, radiation, chemotherapy, surgery, or targeted therapy.…

    • 358 Words
    • 2 Pages
    Good Essays
  • Powerful Essays

    White Blood Cells

    • 1041 Words
    • 5 Pages

    White blood cells, or leukocytes (also spelled "leucocytes"; from the Greek word leuko- meaning "white"), are cells of the immune system involved in defending the body against both infectious disease and foreign materials. Five[1] different and diverse types of leukocytes exist, but they are all produced and derived from a multipotent cell in the bone marrow known as a hematopoietic stem cell. They live for about three to four days in the average human body. Leukocytes are found throughout the body, including the blood and lymphatic system.…

    • 1041 Words
    • 5 Pages
    Powerful Essays

Related Topics