The character's origins lie in the accounts of Kings Duff and Duncan in Holinshed's Chronicles (1587), a history of Britain familiar to Shakespeare. Shakespeare's Lady Macbeth appears to be a composite of two separate and distinct personages in Holinshed's work: Donwald's nagging, murderous wife in the account of King Duff, and Macbeth's ambitious wife Gruoch of Scotland in the account of King Duncan.
Lady Macbeth is a powerful presence in the play, most notably in the first two acts. Following the murder of King Duncan, however, her role in the plot diminishes. She becomes an uninvolved spectator to Macbeth's plotting, and a nervous hostess at a banquet dominated by her husband's hallucinations. Her fifth act sleepwalking scene is a turning point in the play, and her line, "Out, damned spot!," has become a phrase familiar to many speakers of the English language. The report of her death late in the fifth act provides the inspiration for Macbeth's "Tomorrow and tomorrow and tomorrow" speech.
Analysts see in the character of Lady Macbeth the conflict between femininity and masculinity, as they are impressed in cultural norms. Lady Macbeth suppresses her instincts toward compassion, motherhood, and fragility — associated with femininity — in favour of ambition, ruthlessness, and the singleminded pursuit of power. This conflict colours the entire drama, and sheds light on gender-based preconceptions from Shakespearean England to the present.
The role has attracted countless notable actresses over the centuries, including Sarah Siddons, Charlotte Melmoth, Helen Faucit, Ellen Terry, Vivien Leigh, Vivien Merchant, Glenda Jackson, Francesca Annis, Judith Anderson, Renée O'Connor, Judi Dench, Tabu and Keeley Hawes. Jeanette Nolan played the character in Orson Welles' 1948 film adaptation.
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