Lab on Aspirin Tablets

Topics: Aspirin, Purple, Salicylic acid Pages: 6 (1383 words) Published: December 21, 2010



This lab was basically about finding the percentage of acetylsalicylic acid in an aspirin tablet. First, the base was created, which was made out of 1.00 g of NaOH and D-water. Then the buret was attached to the clamp on the ring stand and the base was poured into the buret. After that, one by one, an aspirin tablet was dropped into an Erlenmeyer flask filled with 50 mL of D-water so that it could become dissolved. After the tablet was completely dissolved, a few drops of phenol were added, and the base was added very slowly, changing the color of the mixture into a pink. The flask was to be swiveled around. This was done three times, trying to get the pink color to stay for at least two minutes. Materials:

* D-water
* Scale
* Slop beaker
* Erlenmeyer Flask x3
* Volumetric Flask
* Ring Stand
* Buret
* Buret Clamp
* Phenolphthalein
* NaOH
* Weighing boats
* Aspirin Tablets x3
* Stirring Rod
* Scoopula
The purpose of this lab was to find the percentage of acetylsalicylic acid in an aspirin tablet.
Aspirin possesses a number of properties that make it the most recommended drug pretty often. It is an analgesic, which means that it is very effective in pain relief. Being an anti-inflammatory agent, it is also provides some relief from the swelling associated with arthritis and minor injuries. It also reduces fever because it is an antipyretic compound. More than 40 million pounds of aspirin are produced in the U.S. every year. This rate breaks down to about 300 tablets per year for every woman, man, and child.

However, repeated use may cause gastrointestinal bleeding, and large doses can provoke a host of reactions including vomiting, diarrhea, vertigo, and hallucinations. The average dose is approximately 0.3-1 g, but single doses of 10-30 g can be deadly. The most important compound in the synthesis of aspirin, salicylic acid, is prepared from phenol by a process discovered over 100 years ago by a German chemist Hermann Kolbe. Also known as acetylsalicylic acid, aspirin has a chemical formula of C9H8O4. Aspirin is sold over the counter and comes in many different forms. You can have white tablets to chewing gum and rectal suppositories. Also available are coated, chewable, buffered and extended release forms. Over the counter medicines like Alka-Seltzer Original Effervescent Antacid Pain Reliever, contains aspirin for pain relief.

Aspirin belongs to a group of drugs called salicylates. Aspirin isn’t so easy on the stomach because it is quickly absorbed into the bloodstream and provides quick and relatively long-lasting pain relief. Aspirin also reduces inflammation. Researchers believe these effects come about because aspirin blocks the production of pain-producing chemicals which are called prostaglandins. While it does relieve pain and reduce inflammation, it also lowers fever by acting on the part of the brain that regulates temperature. The brain then sends signals to the blood vessels to widen, which allow any heat to leave the body more effectively.

1. Make 100 mL of 0.20M NaOH solution.
2. Find mass of one tablet.
3. Dissolve tablet in flask using, 50mL of D-water. Use a stirring rod to assist in crushing and dissolving the tablet. There should be some powdery substances on the bottom of the flask, it’s the starches put in the tablets. 4. While one partner is dissolving the tablet the other one should be setting up the buret and stand. Place the clamp on the stand. Next wash the buret with a little D-water before placing the buret on the clamp. Next fill the buret with NaOH solution up to a place above the “O” marking on the buret. Open the buret, to allow some of the base to run into a...
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