Kilocarpines Lab Report

pilocarpine (Fig. 5), 0.45 mg. per kilogram of atropine was administered intraperitoneally. Nine minutes after the atropine, the myopia had increased and then remained high until a larger dose of atropine,
0.8 mg. per kilogram, was given. The pupil contracted maximally during the experiment, and dilated only after the second dose of atropine. The remarkable fluctuations in refraction after 50 mg. per kilogram pilocarpine (Fig. 5) were not due topilocarpine (Fig. 5), 0.45 mg. per kilogram of atropine was administered intraperitoneally. Nine minutes after the atropine, the myopia had increased and then remained high until a larger dose of atropine,
0.8 mg. per kilogram, was given. The pupil contracted maximally during the experiment, and
The remarkable fluctuations in refraction after 50 mg. per kilogram pilocarpine (Fig. 5) were not due to errors of measurements. Each point is in fact the average of several readings in rapid succession and there is no doubt that real fluctuations of refraction took place. The same is true for the dip at 11 minutes after the first atropine dose. This was the only monkey in the present series in which there were such fluctuations and the only one which showed this paradoxical effect on refraction with pilocarpine and atropine.
Fluctuations in refraction have sometimes been seen after systemic carbachol, and with this drug the paradoxical effect on refraction is constantly noted after high doses. 6
Systemic effects of pilocarpine. The monkeys started to salivate after 0.1 mg. per kilogram of pilocarpine. At 0.5 to 1.0 mg. per kilogram the salivation was profuse an errors of measurements. Each point is in fact the average of several readings in rapid succession and there is no doubt that real fluctuations of refraction took place. The same is true for the dip at 11 minutes after the first atropine dose. This was the only monkey in the present series in which there were such fluctuations and the only