JOURNAL YENNI BAHAR Rev1

Testing on the effectiveness of anti acne gel (Acne vulgaris) mild and moderate degree acne from ethanol extract of galanga (Kaemferia galanga L.) in students at Miftahus Salam Boarding School in Banyumas

Yenni Bahar*, Berna Elya*, Mahdi Jufri*
Faculty of Pharmacy, University of Indonesia, Depok 16424, Indonesia
Coresponding author : [e-mail]

ABSTRACT

Acne is an aesthetic skin disorder, usually in adolescents, with a clinical manifestation of comedones, papules, pustules, and nodules.The aim of this research was to asses the antibacterial activity of Kaempferia galanga L rhizome against the P.acne bacteria, to know the physical stability of the Kaempferia galanga L extract gel, its safety, and its effectiveness as an anti acne gel for the treatment of mild to moderate degree of acne. Extraction was done by maceration using 96% ethanol. Antibacterial activity testing was observed at concentrations of 0.75%, 1.25%, 1.75%, and 2.25%. The gel with a concentration of 0.75% had an inhibition zone of 11.5 mm in Brucella medium. Based on the physical stability of the Kaempferia galanga L extract gel, the gel had a good physical stability profile. A safety trial, which was evaluated on 12 students, found no irritation nor allergy. Treament using the Kaempferia galanga L extract gel was given to 30 individuals, and treatment using 1.2% clindamycin was given to the other 30 individuals as the positive control. After 3 weeks of evaluation, Kaempferia galanga L extract gel gave a significant (t < 0.01) improvemet on mild as well as moderate acne.
Key words: galanga rhizome, acne lession, P.acne

INTRODUCTION
The treatment of acne has a very much benefited from the use of several medicinal plants in Indonesia.The use of natural products from plants is nowadays preferred as it is believed to cause fewer side effects than modern medicine made from synthetic materials. One of the most commonly studied rhizomes in the field of aesthetics is the Kaempferia

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