Control hypotension Controlled low blood pressure is another way of reducing blood loss. This method is done by reducing the cardiac output or systemic vascular resistance (Kiran et al, 2014). Hypotension can result from taking specific types of medications such as isoflurane (inhaler), propofol, and nitroglycerin …show more content…
Aprotinin inhibits serine protease and reduces blood loss. However, aprotinin has side effects on heart and renal functions. Therefore, it is usage has been restricted to trial purposes solely (Kiran et al, 2014). Antifibrinolytics is the most commonly used to reduce blood loss. It is a mixture of aprotinin and lysine analogous (tranexamic acid and ε-aminocaproic acid). Tranexamic acid and ε-aminocaproic acid inhibited the plasmin that mediate the fibrin breakdown. In other words, they halt the plasminogen from converting into plasmin, which then the plasmin activate the fibrinolysis. Desmopressin is a compound similar to vasopressin. It triggers the production of Von Willebrand factor and factor VIII, which activate the platelets aggregation. Therefore, desmopressin used to treat Von Willebrand disease and hemophilia. That means the desmopressin can be used to halt the