Immipramine Research Paper
INTRODUCTION :
Imipramine belongs to a group of medicines called tricyclic antidepressants. It affects chemicals in the brain that may become unbalanced. It is generally used to treat symptoms of depression. However, it is also used to treat a completely unrelated condition in children, known as nocturnal enuresis (night-time bedwetting).
TRADE NAMES :
TofranilAntidepAntipresMicrodepPraminGENERIC NAME : Imipramine hydrochloride
ACTION : Antidepressant
AVAILABLE FORMS :
Tablets (imipramine hydrochloride)—10, 25, 50 mg; capsules (imipramine pamoate)—75, 100, 125, 150 mg
DOSAGE/ROUTE :
Adults
Depression: Hospitalized patients: initially, 100–150 mg/day PO in divided doses. Gradually increase to 200 mg/day as required. If no response …show more content…
Peak plasma levels are reached in 2 to 5 hours, and plasma half-life ranges from 9 to 20 hours.
After oral administration of 50 mg 3 times daily for 10 days, the mean steady-state plasma concentration was 33 to 85 ng/mL for imipramine and 43 to 109 ng/mL for desmethylimipramine, an active metabolite.
Approximately 86% of imipramine is bound to plasma proteins.
It is excreted primarily as inactive metabolites, up to 80% in the urine and up to 20% in the feces.
Owing to the lower clearance of imipramine in plasma, elderly patients require lower doses of imipramine than patients in younger age groups.
DRUG INTERACTIONS : phenytoinany other antidepressant, or medication to treat mental illness bladder or urinary medicines such as darifenacin, tolterodine, solifenacinbronchodilators such as ipratropium or tiotropiumcold or allergy medicine that contains an antihistamine medication for Parkinson's disease; or medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel …show more content…
Do not stop taking drug abruptly or without consulting your health care provider.
Avoid prolonged exposure to sunlight or sunlamps; use a sunscreen or protective garments.
These side effects may occur: headache, dizziness, drowsiness, weakness, blurred vision (reversible; safety measures may need to be taken if severe; avoid driving or performing tasks that require alertness); nausea, vomiting, loss of appetite (small frequent meals, frequent mouth care may help); dry mouth (sucking sugarless candies may help); disorientation, difficulty concentrating, emotional changes; changes in sexual function, impotence, changes in libido.
Report dry mouth, difficulty in urination, excessive sedation, fever, chills, sore throat, palpitations.
CONCLUSION :
Imipramine, sold as Tofranil and also known as melipramine, is a HYPERLINK "http://en.wikipedia.org/wiki/Tricyclic_antidepressant" \o "Tricyclic antidepressant" tricyclic antidepressant (TCA) of the HYPERLINK "http://en.wikipedia.org/wiki/Dibenzazepine" \o "Dibenzazepine" dibenzazepine group. Imipramine is mainly used in the treatment of major depression and enuresis (inability to control urination).It has also been evaluated for use in panic
Imipramine belongs to a group of medicines called tricyclic antidepressants. It affects chemicals in the brain that may become unbalanced. It is generally used to treat symptoms of depression. However, it is also used to treat a completely unrelated condition in children, known as nocturnal enuresis (night-time bedwetting).
TRADE NAMES :
TofranilAntidepAntipresMicrodepPraminGENERIC NAME : Imipramine hydrochloride
ACTION : Antidepressant
AVAILABLE FORMS :
Tablets (imipramine hydrochloride)—10, 25, 50 mg; capsules (imipramine pamoate)—75, 100, 125, 150 mg
DOSAGE/ROUTE :
Adults
Depression: Hospitalized patients: initially, 100–150 mg/day PO in divided doses. Gradually increase to 200 mg/day as required. If no response …show more content…
Peak plasma levels are reached in 2 to 5 hours, and plasma half-life ranges from 9 to 20 hours.
After oral administration of 50 mg 3 times daily for 10 days, the mean steady-state plasma concentration was 33 to 85 ng/mL for imipramine and 43 to 109 ng/mL for desmethylimipramine, an active metabolite.
Approximately 86% of imipramine is bound to plasma proteins.
It is excreted primarily as inactive metabolites, up to 80% in the urine and up to 20% in the feces.
Owing to the lower clearance of imipramine in plasma, elderly patients require lower doses of imipramine than patients in younger age groups.
DRUG INTERACTIONS : phenytoinany other antidepressant, or medication to treat mental illness bladder or urinary medicines such as darifenacin, tolterodine, solifenacinbronchodilators such as ipratropium or tiotropiumcold or allergy medicine that contains an antihistamine medication for Parkinson's disease; or medication to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel …show more content…
Do not stop taking drug abruptly or without consulting your health care provider.
Avoid prolonged exposure to sunlight or sunlamps; use a sunscreen or protective garments.
These side effects may occur: headache, dizziness, drowsiness, weakness, blurred vision (reversible; safety measures may need to be taken if severe; avoid driving or performing tasks that require alertness); nausea, vomiting, loss of appetite (small frequent meals, frequent mouth care may help); dry mouth (sucking sugarless candies may help); disorientation, difficulty concentrating, emotional changes; changes in sexual function, impotence, changes in libido.
Report dry mouth, difficulty in urination, excessive sedation, fever, chills, sore throat, palpitations.
CONCLUSION :
Imipramine, sold as Tofranil and also known as melipramine, is a HYPERLINK "http://en.wikipedia.org/wiki/Tricyclic_antidepressant" \o "Tricyclic antidepressant" tricyclic antidepressant (TCA) of the HYPERLINK "http://en.wikipedia.org/wiki/Dibenzazepine" \o "Dibenzazepine" dibenzazepine group. Imipramine is mainly used in the treatment of major depression and enuresis (inability to control urination).It has also been evaluated for use in panic