Hypercholesterolemia Research Paper

What is hypercholesterolemia?
Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.
People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). The abnormal buildup of cholesterol forms clumps (plaque) that narrow and harden artery walls. As the clumps get bigger, they can clog the arteries and restrict the flow of blood to the heart. The buildup of plaque in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack.
Inherited forms of hypercholesterolemia can also cause health problems related to the buildup of excess cholesterol in other tissues. If cholesterol
Cholesterol is manufactured primarily in the liver and then carried to the cells throughout the body by low-density lipoprotein (LDL). Because cholesterol and other fats do not dissolve in water, they cannot travel through the body unaided. Lipoproteins are particles formed in the liver to transport cholesterol and other fats through the bloodstream. Cholesterol is returned to the liver from other body cells by another lipoprotein, high-density lipoprotein (HDL). From there, cholesterol is secreted into the bile, either unchanged or after conversion to bile